Auranofin

• Catalog number
  2219-50
• Price
  Please ask
• Size
  50 mg

• Alternative_name
  1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate; SKF39162
• Description
  An anti-arthritic drug that inhibits various leukocyte activation pathways at multiple sites. Inhibits release of inflammatory mediators from human basophils, pulmonary mast cells and macrophages. Also inhibits human neutrophil 5-lipoxygenase. Inhibits IκB kinase (IKK) by modifying Cys179 of the IKKß subunit. Efficient inducer of mitochondrial membrane permeability transition via the inhibition of mitochondrial thioredoxin reductase (TrxR).
• CAS Number
  34031-32-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₀H₃₄AuO₉PS
• Molecular Weight
  678.48
• Cell Permeable
  Yes
• Purity
  ≥98% by NMR
• Solubilities
  DMSO (100 mM) or Ethanol (50 mM)
• Handling
  Protect from light and moisture
• Tag Line
  Leukocyte activation pathways inhibitor
• Storage Condition
  RT
• Shipping Condition
  RT
• Shelf Life
  24 months
• MDL Number
  MFCD00080759
• PubChem CID
  24199313
• PubChem CID Link
• SMILES
  CCP(CC)CC.CC(=O)OCC1C(C(C(C(O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.[Au+]
• InChi
  InChI=1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/q;;+1/p-1
• InChi Key
  AUJRCFUBUPVWSZ-UHFFFAOYSA-M
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Auranofin  
• Short name
  Auranofin
• Alternative name
  Auranofin

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