Anti-Irisin Antibody
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Catalog numberA1459-100
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PricePlease ask
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Size100 µg
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Antibody TargetIrisin
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Target Alternative NameFibronectin Type III Domain-containing Protein 5, FNDC5 (cleaved); Fibronectin Type III Repeat-containing Protein 2, FRCP2 (cleaved)
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Antibody TypePolyclonal
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Species ReactivitiesHuman, Mouse, Rat
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Immunogen SequenceHuman recombinant Irisin
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AccessionQ8NAU1
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Gene Id252995
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AppearanceColorless liquid
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FormLiquid
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FormulationIn PBS pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% Proclin
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PurificationAffinity purified
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ApplicationWB
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Positive ControlWB: Rat kidney lysate, Human recombinant Irisin
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Application And UsagesWB: 1-4 µg
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DescriptionIrisin is a recently discovered exercise-induced myokine, which is secreted by skeletal muscles and produced by cleavage of the FNDC5. Studies show that Irisin stimulates mitochondria uncoupling protein-1 (UCP-1; a regulator of thermogenic capability of brown fat) expression, so Irisin can upregulate white to brown fat conversion and improve systemic metabolism by increasing energy expenditure. Hence, Irisin is a potential new drug target in the study of metabolic disorders, such as obesity and type 2 diabetes mellitus (T2DM). Moreover, FNDC5-like receptors are conserved in vertebrates and critical for neuronal development.
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Storage Condition-20 °C
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Shipping Conditiongel pack
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Shelf Life12 months
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UsageFor Research Use Only! Not to be used in humans
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HandlingThe antibody solution should be gently mixed before use
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Western Blot VerifiedVerified
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Immunocytochemistry VerifiedNot Verified
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Immunofluorescence VerifiedNot Verified
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Immunoprecipitation VerifiedNot Verified
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FACS VerifiedNot Verified
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ELISA VerifiedNot Verified
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ChIP VerifiedNot Verified
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Dot Blot VerifiedNot Verified
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Flow Cytometry VerifiedNot Verified
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Additional descriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolFNDC5
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Short nameAnti-Irisin Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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IsotypeRabbit IgG
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Alternative nameAntibody toIrisin (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namefibronectin type III domain containing 5
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2004-01-13
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Fibronectin type III domain containing
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data