DC-SIGN Antibody, ALEXA FLUOR 594

• Catalog number
  bs-2557R-A594
• Price
  Please ask
• Size
  100ul

• Long name
  DC-SIGN Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
• Also known as
  Anti-DC-SIGN PAb ALEXA FLUOR 594
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 594
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  DC-SIGN
• Specificity
  This is a highly specific antibody against DC-SIGN.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  354-404/404
• Subcellular location
  Extracellular
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DC-SIGN
• Gene ID Number
  30835
• Swiss Prot
  Q9NNX6
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  590nm/617nm
• Synonyms
  CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; CD209 antigen; C-type lectin domain family 4 member L; Dendritic cell-specific ICAM-3-grabbing non-integrin 1; CD209
• Properties
  For facs or microscopy Alexa 1 conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• French translation
  anticorps

• Gene target
  DC-SIGN  
• Gene symbol
  CD209, CLEC4M, UBTD2, WFDC21P, TSPAN14, DCSTAMP, DCX, LAMP3, PDCD1LG2, CCL18
• Short name
  Anti-DC-SIGN
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  DC-SIGN Polyclonal Antibody, ALEXA FLUOR 594
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:1641
• Gene
  CD209
• Long gene name
  CD209 molecule
• Synonyms gene name
  • CD209 antigen
• Synonyms
  • DC-SIGN
  • hDC-SIGN
  • CDSIGN
  • DC-SIGN1
  • CLEC4L
• GenBank acession
  • M98457
• Locus
  19p13.2
• Discovery year
  2000-07-19
• Entrez gene record
  30835
• Pubmed identfication
  • 1518869
• RefSeq identity
  • NM_021155
• Classification
  • Scavenger receptors
  • C-type lectin domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000182530

Gene info

• Identity
  HGNC:13523
• Gene
  CLEC4M
• Long gene name
  C-type lectin domain family 4 member M
• Synonyms gene
  • CD209L
  • CD299
• Synonyms gene name
  • CD299 antigen
  • C-type lectin domain family 4, member M
• Synonyms
  • HP10347
  • DC-SIGNR
  • LSIGN
  • DCSIGNR
  • DC-SIGN2
• GenBank acession
  • AB015629
• Locus
  19p13.2
• Discovery year
  2000-09-19
• Entrez gene record
  10332
• Pubmed identfication
  • 10072769
• RefSeq identity
  • NM_014257
• Classification
  • CD molecules
• VEGA ID
  OTTHUMG00000182432

Gene info

• Identity
  HGNC:24463
• Gene
  UBTD2
• Long gene name
  ubiquitin domain containing 2
• Synonyms
  • DC-UbP
  • MGC30022
• Synonyms name
  • dendritic cell derived ubiquitin like protein
• GenBank acession
  • AF251700
• Locus
  5q35.1
• Discovery year
  2006-11-06
• Entrez gene record
  92181
• Pubmed identfication
  • 12507522
• RefSeq identity
  • NM_152277
• VEGA ID
  OTTHUMG00000130519

Gene info

• Identity
  HGNC:50357
• Gene
  WFDC21P
• Long gene name
  WAP four-disulfide core domain 21, pseudogene
• Synonyms
  • LOC645638
  • lnc-DC
  • LNCDC
• Synonyms name
  • long non-coding RNA, dendritic cell differentiation
  • WDNM1-like, pseudogene
  • lnc-dendritic cell lncRNA
• Locus
  17q23.1
• Discovery year
  2014-06-16
• Entrez gene record
  645638
• Pubmed identfication
  • 24744378
  • 26158411
• RefSeq identity
  • NR_030732
• VEGA ID
  OTTHUMG00000176074

Gene info

• Identity
  HGNC:23303
• Gene
  TSPAN14
• Long gene name
  tetraspanin 14
• Synonyms gene
  • TM4SF14
• Synonyms gene name
  • transmembrane 4 superfamily member 14
• Synonyms
  • DC-TM4F2
  • MGC11352
• GenBank acession
  • AF311903
• Locus
  10q23.1
• Discovery year
  2004-10-19
• Entrez gene record
  81619
• Pubmed identfication
  • 11230166
• RefSeq identity
  • NM_030927
• Classification
  • Tetraspanins
• VEGA ID
  OTTHUMG00000018615

Gene info

• Identity
  HGNC:18549
• Gene
  DCSTAMP
• Long gene name
  dendrocyte expressed seven transmembrane protein
• Synonyms gene
  • TM7SF4
• Synonyms gene name
  • transmembrane 7 superfamily member 4
• Synonyms
  • DC-STAMP
  • FIND
• Synonyms name
  • Dendritic cells (DC)-specific transmembrane protein
  • IL-Four INDuced
• GenBank acession
  • AF305068
• Locus
  8q22.3
• Discovery year
  2004-06-25
• Entrez gene record
  81501
• Pubmed identfication
  • 11169400
  • 11345591
• RefSeq identity
  • NM_030788
• VEGA ID
  OTTHUMG00000164890

Gene info

• Identity
  HGNC:2714
• Gene
  DCX
• Long gene name
  doublecortin
• Synonyms gene name
  • doublecortex; lissencephaly, X-linked (doublecortin)
• Synonyms
  • SCLH
  • DC
  • LISX
  • DBCN
  • XLIS
• Synonyms name
  • doublecortex
• GenBank acession
  • AF040254
• Locus
  Xq23
• Discovery year
  1998-03-24
• Entrez gene record
  1641
• Pubmed identfication
  • 9489699
  • 9489700
• RefSeq identity
  • NM_178153
• Classification
  • Doublecortin superfamily
• VEGA ID
  OTTHUMG00000022204

Gene info

• Identity
  HGNC:14582
• Gene
  LAMP3
• Long gene name
  lysosomal associated membrane protein 3
• Synonyms gene name
  • lysosomal-associated membrane protein 3
• Synonyms
  • LAMP
  • TSC403
  • DC-LAMP
  • DCLAMP
  • CD208
• GenBank acession
  • AB013924
• Locus
  3q27.1
• Discovery year
  2001-06-29
• Entrez gene record
  27074
• Pubmed identfication
  • 9721848
• Classification
  • Lysosome associated membrane proteins
  • CD molecules
• VEGA ID
  OTTHUMG00000158387

Gene info

• Identity
  HGNC:18731
• Gene
  PDCD1LG2
• Long gene name
  programmed cell death 1 ligand 2
• Synonyms
  • PD-L2
  • Btdc
  • PDL2
  • bA574F11.2
  • CD273
  • B7-DC
• Synonyms name
  • B7 dendritic cell molecule
• GenBank acession
  • AF344424
• Locus
  9p24.1
• Discovery year
  2003-11-14
• Entrez gene record
  80380
• Pubmed identfication
  • 11224527
• RefSeq identity
  • NM_025239
• Classification
  • B7 family
  • CD molecules
  • Immunoglobulin like domain containing
  • Receptor ligands
• VEGA ID
  OTTHUMG00000019504

Gene info

• Identity
  HGNC:10616
• Gene
  CCL18
• Long gene name
  C-C motif chemokine ligand 18
• Synonyms gene
  • SCYA18
• Synonyms gene name
  • small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated
  • chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
  • chemokine (C-C motif) ligand 18
• Synonyms
  • DC-CK1
  • PARC
  • AMAC-1
  • DCCK1
  • MIP-4
  • CKb7
• Synonyms name
  • pulmonary and activation-regulated
• GenBank acession
  • Y13710
• Locus
  17q12
• Discovery year
  1997-01-08
• Entrez gene record
  6362
• Pubmed identfication
  • 9233607
  • 10049593
• RefSeq identity
  • NM_002988
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000188410

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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