Tipifarnib, Free base

• Catalog number
  2296-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one; R-115777
• Description
  A potent, selective, nonpeptidomimetic inhibitor of farnesyl protein transferase (FPT), an enzyme involved in protein processing (farnesylation) for signal transduction. Displays significant antitumor effects in vivo.  Tipifarnib competitively inhibits the farnesylation of lamin B (IC₅₀ = 0.86 nM) and K-RasB (IC₅₀ = 7.9 nM) peptide substrates and inhibits the cell growth of ~75% of a panel of 53 human tumor cell lines tested.
• CAS Number
  192185-72-1
• Structure Available
  Yes
• Peptide sequence
  No
• Salt Form
  No
• Molecular Formula
  C₂₇H₂₂Cl₂N₄O
• Molecular Weight
  489.4
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~ 15 mg/ml) or Ethanol (~ 10 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent farnesyl protein transferase (FPT) inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD09837802
• PubChem CID
  159324
• PubChem CID Link
• SMILES
  CN1C=NC=C1C(C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N
• InChi
  InChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m1/s1
• InChi Key
  PLHJCIYEEKOWNM-HHHXNRCGSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Tipifarnib   Free   base  
• Short name
  Tipifarnib, Free base
• Alternative name
  Tipifarnib, Free base

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