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FAM161A Polyclonal Antibody

FAM161A Polyclonal Antibody is available 8 times from Epigen labs

A64930-100 | FAM161A Polyclonal Antibody size: 100 µg | 493.21 USD

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A64930-050 | FAM161A Polyclonal Antibody size: 50 µg | 368.19 USD

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A64933-050 | FAM161A Polyclonal Antibody, Biotin Conjugated size: 50 µg | 368.19 USD

Catalog number A64933-050
Supplier Epigen
Price368.19 USD
Size 50 µg
Storage Our specialists from Gentaur/Genprice advise to follow carefully the instructions for use and store the FAM161A Polyclonal Antibody, Biotin Conjugated in refrigerator and according to the label upon arrival.
Properties If you buy Antibodies supplied by Epigen they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6.
Conjugation Biotinylated
Group Polyclonals and antibodies
About Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
French translation anticorps
Gene targetFAM161A Conjugated
Short name FAM161A Polyclonal Antibody, Conjugated
Technique Polyclonal, Antibody
Label Biotin
Alternative name FAM161A polyclonal (Antibody to), biotinilated coupled
1. Gene info
Identity25808
Long gene name family with sequence similarity 161 member A
Synonyms gene
Synonyms gene name
  • retinitis pigmentosa 28 (autosomal recessive)
  • family with sequence similarity 161, member A
Synonyms
Locus2p15
Discovery year 2008-06-05
Entrez gene record84140
Pubmed identfication
RefSeq identity
Havana BLAST/BLATOTTHUMG00000152165
MeSH Data
Concept
Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
Additional information
PubMedThese data suggest a pivotal role for FAM161A in photoreceptors and reveal that FAM161A loss-of-function mutations are a major cause of autosomal-recessive Retinitis pigmentosa.
FAM161A is a microtubule-associated ciliary protein presumably involved in microtubule stabilization to maintain the microtubule tracks and/or in transport processes along microtubules in photoreceptors and other retinal cell types.
FAM161A-associated RP can be considered as a novel retinal ciliopathy and that its molecular pathogenesis may be related to other ciliopathies.
an RP28 (an autosomal recessive form of retinitis pigmentosa)-linked RP family in the Palestinian population caused by a novel nonsense mutation in FAM161A, was identified.
Our data indicate that mutations in FAM161A are responsible for 1% of recessive RP cases in North America, similar to the prevalence detected in Germany and unlike the data from Israel and the Palestinian territories.
FAM161A is a novel centrosomal-ciliary protein that likely is implicated in the regulation of microtubule-based cellular processes in the retina.
Exome analysis revealed a nonsense homozygous mutation in FAM161A segregating with retinal degeneration with severe vision loss and a range of disease onset and progression.
FAM161A's activities are probably not limited to ciliary tasks but also extend to more general cellular functions, highlighting possible novel mechanisms for the molecular pathology of retinal disease.
We screened a panel of 120 probands with recessive Retinitis Pigmentosa, and two were found to harbour biallelic FAM161A variants.
novel homozygous frameshift mutations of RP28-linked RP gene FAM161A in Indian population.
Gene ontology - Molecular functionprotein binding
identical protein binding

A64933-100 | FAM161A Polyclonal Antibody, Biotin Conjugated size: 100 µg | 493.21 USD

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A64932-100 | FAM161A Polyclonal Antibody, FITC Conjugated size: 100 µg | 493.21 USD

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A64932-050 | FAM161A Polyclonal Antibody, FITC Conjugated size: 50 µg | 368.19 USD

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A64931-050 | FAM161A Polyclonal Antibody, HRP Conjugated size: 50 µg | 368.19 USD

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A64931-100 | FAM161A Polyclonal Antibody, HRP Conjugated size: 100 µg | 493.21 USD

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Tips Manufactured in United States. Designed for Research Use Only, not for human or animal consumption.
Alternative technique polyclonals
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