VX-745

• Catalog number
  2812-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-one
• Description
  VX-745 is a potent and selective inhibitor of p38α (IC₅₀ = 10 nM). It displays 22-fold greater selectivity versus p38β and no inhibition of p38γ. Also blocks TNFα production in LPS-stimulated HWB in vitro (IC₅₀ = 177 nM).
• CAS Number
  209410-46-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₉H₉Cl₂F₂N₃OS
• Molecular Weight
  436.26
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~40 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent and selective inhibitor of p38α
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• MDL Number
  MFCD09834070
• PubChem CID
  3038525
• PubChem CID Link
• SMILES
  C1=CC(=C(C(=C1)Cl)C2=C3C=CC(=NN3C=NC2=O)SC4=C(C=C(C=C4)F)F)Cl
• InChi
  InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H
• InChi Key
  VEPKQEUBKLEPRA-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  VX-745  
• Short name
  VX-745
• Alternative name
  VX-745

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