PJ-34,PARP inhibitor

Research Area s

Cancer , Apoptosis , Cancer Growth Inhibitors , PARP Inhibitors
Category

Small Molecules
Product Type

Inhibitor
CAS No

344458-15-7
MolecularFormula

C17H17N3O2•HCL•H2O
Molecular Weight

331.8
Purity

≥98% (HPLC); NMR (Conforms)
Solubility

May be dissolved in DMSO (30 mg/ml) or water (20 mg/ml)
Appearance

White to yellow solid.
Storage Temperature

-20°C
Shipping Temperature

Shipped Ambient
Description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Gene target

PJ-34 PARP inhibitor
Gene symbol

SNORD115-34, IGKV3D-34, IGHV4-34, IGKV3-34, IGLV2-34, IGHV7-34-1, TNKS2, TIPARP, PARP1, RNU6-34P
Short name

PJ-34 PARP inhibitor
Alternative name

PJ-34,PARP suppressor

Identity

HGNC:5828
Gene

IGKV3D-34
Long gene name

immunoglobulin kappa variable 3D-34 (pseudogene)
Synonyms gene name
- immunoglobulin kappa variable 3D-34
- immunoglobulin kappa variable 3D-34 pseudogene
GenBank acession
- X71895
Locus

2p11.2
Discovery year

2000-04-18
Entrez gene record

28871
RefSeq identity
- NG_000833
Classification
- Immunoglobulin kappa locus at 2p11.2
VEGA ID

OTTHUMG00000151601

Identity

HGNC:5820
Gene

IGKV3-34
Long gene name

immunoglobulin kappa variable 3-34 (pseudogene)
Synonyms gene name
- immunoglobulin kappa variable 3-34
- immunoglobulin kappa variable 3-34 pseudogene
GenBank acession
- X71891
Locus

2p11.2
Discovery year

2000-04-18
Entrez gene record

28909
RefSeq identity
- NG_000834
Classification
- Immunoglobulin kappa locus at 2p11.2
VEGA ID

OTTHUMG00000151693

Identity

HGNC:5893
Gene

IGLV2-34
Long gene name

immunoglobulin lambda variable 2-34 (pseudogene)
Synonyms gene name
- immunoglobulin lambda variable 2-34
- immunoglobulin lambda variable 2-34 pseudogene
GenBank acession
- D87013
Locus

22q11.22
Discovery year

2000-05-08
Entrez gene record

28810
RefSeq identity
- NG_000002
Classification
- Immunoglobulin lambda locus at 22q11.2
VEGA ID

OTTHUMG00000151174

Identity

HGNC:5664
Gene

IGHV7-34-1
Long gene name

immunoglobulin heavy variable 7-34-1 (pseudogene)
Synonyms gene name
- immunoglobulin heavy variable 7-34-1
- immunoglobulin heavy variable 7-34-1 pseudogene
GenBank acession
- AB019439
Locus

14q32.33
Discovery year

2000-04-04
Entrez gene record

28382
RefSeq identity
- NG_001019
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000152085

Identity

HGNC:15677
Gene

TNKS2
Long gene name

tankyrase 2
Synonyms gene name
- tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Synonyms
- TNKL
- TANK2
- PARP-5b
- PARP-5c
- PARP5B
- PARP5C
- pART6
- ARTD6
Synonyms name
- TRF1-interacting ankyrin-related ADP-ribose polymerase 2
GenBank acession
- AF342982
Locus

10q23.32
Discovery year

2001-05-10
Entrez gene record

80351
RefSeq identity
- NM_025235
Classification
- Poly(ADP-ribose) polymerases
- Sterile alpha motif domain containing
- Ankyrin repeat domain containing
VEGA ID

OTTHUMG00000018747

Identity

HGNC:270
Gene

PARP1
Long gene name

poly(ADP-ribose) polymerase 1
Synonyms gene
- PPOL
- ADPRT
Synonyms gene name
- ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
- poly (ADP-ribose) polymerase family, member 1
Synonyms
- PARP
- ARTD1
GenBank acession
- BC037545
Locus

1q42.12
Discovery year

1986-01-01
Entrez gene record

142
Pubmed identfication
- 10964595
RefSeq identity
- NM_001618
Classification
- Zinc fingers PARP-type
- Zinc fingers
- Poly(ADP-ribose) polymerases
VEGA ID

OTTHUMG00000037556