JW55

Alternative_name

N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide
Description

JW55 is a small molecule inhibitor of the Wnt/β-catenin signaling pathway that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2), regulators of the β-catenin destruction complex. Inhibition of TNKS1/2 poly(ADP-ribosyl)ation activity by JW55 leads to stabilization of AXIN2, a member of the β-catenin destruction complex, followed by increased degradation of β-catenin. In a dose-dependent manner, JW55 inhibits canonical Wnt signaling in colon carcinoma cells that contained mutations in either the APC (adenomatous polyposis coli) locus or in an allele of β-catenin.
CAS Number

664993-53-7
Structure Available

Y
Salt Form

No
Molecular Formula

C₂₅H₂₆N₂O₅
Molecular Weight

434.48
Cell Permeable

Yes
Purity

>98% by HPLC
Solubilities

DMSO(~ 40 mg/ml) or EtOH (~ 40 mg/ml)
Handling

Protect from air and light
Tag Line

A Wnt/β-catenin signaling pathway inhibitor
Storage Condition

-20 ̊C
Shipping Condition

Gel pack
Shelf Life

36 months
PubChem CID

2946601
PubChem CID Link
SMILES

O=C(NC1=CC=C(C(NCC2(C3=CC=C(OC)C=C3)CCOCC2)=O)C=C1)C4=CC=CO4
InChi

InChI=1S/C25H26N2O5/c1-30-21-10-6-19(7-11-21)25(12-15-31-16-13-25)17-26-23(28)18-4-8-20(9-5-18)27-24(29)22-3-2-14-32-22/h2-11,14H,12-13,15-17H2,1H3,(H,26,28)(H,27,29)
InChi Key

ZJZWZIXSGNFWQQ-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes