Human CellExp™ PDGF-CC, Human Recombinant
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Catalog numberP1526-10
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PricePlease ask
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Size10 µg
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SynonymsPlatelet-derived growth factor C, PDGFCC; PDGF-CC, Fallotein, Spinal cord-derived growth factor, SCDGF, VEGF-E
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Alternative_namesPlatelet-derived growth factor C, PDGFCC; PDGF-CC, Fallotein, Spinal cord-derived growth factor, SCDGF, VEGF-E
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DescriptionPotent mitogen for a variety of cell types
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Recombinant1
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SourceHEK 293 cells
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Purity by SDS PAGE>95%
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AssaySDS - PAGE
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Molecular Weight16 kDa (6×His tag at the C-terminus)
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Storage Temp-20°C
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ShippingGel Pack
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Shelf Life12 months
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AppearanceLyophilized powder
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Physical form descriptionLyophilized
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Reconstitution InstructionsCentrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
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Background InformationPDGF-CC is a member of the platelet-derived growth factor (PDGF) family, which was originally identified as a serum growth factor for fibroblasts, smooth muscle cells and glia cells. The PDGF family consists of proteins derived from four genes (PDGF-A, -B, -C, and -D) that form four disulfide-linked homodimers (PDGF-AA, -BB, -CC, and -DD) and one heterodimer (PDGF-AB). These proteins regulate diverse cellular functions by binding to and inducing the homo- or hetero-dimerization of two receptor tyrosine kinases (PDGF R alpha and R beta). PDGF-CC is expressed in multiple embryonic and adult cell types and tissues. PDGF-CC is involved in pathogenesis of neurologic diseases, cancer and fibrosis. The PDGF-CC ligand has also been shown to be involved in tumor growth by paracrine signaling through PDGFRα in malignant melanoma and cervical carcinoma.
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Amino acid sequenceaa Val 235 – Gly 345
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolPDGFA, CCR3, CCR4, CCR2, CCR5
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Short nameCellExp™ PDGF-CC, Recombinant
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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SpeciesHumans
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Alternative nameH. sapiens CellExp™ PDGF-CC, H. sapiens Rec.
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene nameplatelet derived growth factor subunit A
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Synonyms gene name
- platelet-derived growth factor alpha polypeptide
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Synonyms
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Synonyms name
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameC-C motif chemokine receptor 3
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Synonyms gene
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Synonyms gene name
- chemokine (C-C motif) receptor 3
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Synonyms
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GenBank acession
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Locus
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Discovery year1995-05-30
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Entrez gene record
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Classification
- C-C motif chemokine receptors
- CD molecules
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameC-C motif chemokine receptor 4
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Synonyms gene name
- chemokine (C-C motif) receptor 4
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Synonyms
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GenBank acession
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Locus
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Discovery year1996-05-15
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Entrez gene record
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Pubmed identfication
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Classification
- C-C motif chemokine receptors
- CD molecules
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameC-C motif chemokine receptor 2
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Synonyms gene
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Synonyms gene name
- chemokine (C-C motif) receptor 2
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Synonyms
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Locus
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Discovery year1995-05-30
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C-C motif chemokine receptors
- CD molecules
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameC-C motif chemokine receptor 5
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Synonyms gene
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Synonyms gene name
- chemokine (C-C motif) receptor 5
- chemokine (C-C motif) receptor 5 (gene/pseudogene)
- C-C motif chemokine receptor 5 (gene/pseudogene)
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Synonyms
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Locus
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Discovery year1996-05-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C-C motif chemokine receptors
- CD molecules
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data