SB-431542

• Catalog number
  1674-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
• Description
  A potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC₅₀ = 94 nM). It inhibits ALK4 only at higher concentrations (IC₅₀ = 140 nM). Suppresses renewal in embryonic and induced pluripotent stem (iPS) cells and promotes their differentiation through its effect on Smad signaling pathway.
• CAS Number
  301836-41-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₂H₁₈N₄O₃
• Molecular Weight
  384.39
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (20 mg/ml) or EtOH (2 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  TGF-β1 receptor (ALK5) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD11045982
• PubChem CID
  4521392
• PubChem CID Link
• SMILES
  C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
• InChi
  InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1- 2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25, 26)
• InChi Key
  FHYUGAJXYORMHI-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  SB-431542  
• Short name
  SB-431542
• Alternative name
  SB-431542

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