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Alternative_name
1-Isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide
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Description
A potent histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor (IC₅₀ = 2 nM). UNC1999 is >1000-fold selective for other HMTs except EZH1 (22-fold selectivity). It inhibits H3K27 methylation in MCF10A cells with an IC₅₀ of 124 nM as measured by immunofluorescence.
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CAS Number
1431612-23-5
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₃₃H₄₃N₇O₂
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Molecular Weight
569.74
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (~15 mg/ml)
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Handling
Protect from air and light
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Tag Line
A potent EZH2 methyltransferase inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
24 months
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SMILES
CC1=CC(CCC)=C(CNC(C2=C(C=NN3C(C)C)C3=CC(C4=CN=C(N5CCN(C(C)C)CC5)C=C4)=C2)=O)C(N1)=O
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InChi
InChI=1S/C33H43N7O2/c1-7-8-24-15-23(6)37-33(42)28(24)19-35-32(41)27-16-26(17-30-29(27)20-36-40(30)22(4)5)25-9-10-31(34-18-25)39-13-11-38(12-14-39)21(2)3/h9-10,15-18,20-22H,7-8,11-14,19H2,1-6H3,(H,35,41)(H,37,42)
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InChi Key
DPJNKUOXBZSZAI-UHFFFAOYSA-N
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MSDS Available
Yes