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Alternative_name
N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide;phosphoric acid
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Description
Motesanib (AMG-706), is an orally bioavailable multiple-receptor tyrosine kinase inhibitor with potential antineoplastic activity. Motesanib selectively targets and inhibits vascular endothelial growth factor (VEGFR), platelet-derived growth factor (PDGFR), kit, and Ret receptors, thereby inhibiting angiogenesis and cellular proliferation.
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CAS Number
857876-30-3
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₂H₂₉N₅O₉P₂
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Molecular Weight
569.4
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO
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Handling
Protect from air and light
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Tag Line
An orally bioavailable multiple-receptor tyrosine kinase inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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PubChem CID
16097729
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SMILES
CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C.OP(=O)(O)O.OP(=O)(O)O
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InChi
InChI=1S/C22H23N5O.2H3O4P/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15;2*1-5(2,3)4/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28);2*(H3,1,2,3,4)
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InChi Key
ONDPWWDPQDCQNJ-UHFFFAOYSA-N
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MSDS Available
Yes
