SCH-529704
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Catalog number9438-25
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PricePlease ask
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Size25 mg
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Alternative_nameN3-[2-[[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine
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DescriptionSCH-529074 is a small molecule activator of mutant p53. It binds specifically to the p53 DBD (DNA binding domain) in a saturable manner with an affinity of 1-2 µM. Binding restores wild type function to many oncogenic mutant forms of p53. SCH-529074 reactivates mutant p53 by acting as a chaperone. In addition to reactivating mutant p53, SCH-529074 binding inhibits ubiquitination of p53 by HDM2.
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CAS Number922150-11-6
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₃₁H₃₆Cl₂N₆
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Molecular Weight563.56
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Cell PermeableYes
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Purity≥98%
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SolubilitiesDMSO (>40 mg/ml)
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HandlingProtect from air and light
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Tag LineAn activator of mutant p53
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID12001922
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SMILESCN(C)CCCNC1=NC(=NC2=CC=CC=C21)CN3CCN(CC3)C(C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
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InChiInChI=1S/C31H36Cl2N6/c1-37(2)17-5-16-34-31-27-6-3-4-7-28(27)35-29(36-31)22-38-18-20-39(21-19-38)30(23-8-12-25(32)13-9-23)24-10-14-26(33)15-11-24/h3-4,6-15,30H,5,16-22H2,1-2H3,(H,34,35,36)
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InChi KeyNCAJLQDPTZBGJV-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolNF2
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Short nameSCH-529704
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Alternative nameSCH-529704
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Gene info
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Identity
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Gene
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Long gene nameNF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
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Synonyms gene name
- neurofibromin 2 (bilateral acoustic neuroma)
- neurofibromin 2 (merlin)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1992-01-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- FERM domain containing
- A-kinase anchoring proteins
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VEGA ID
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Locus Specific Databases