SCH-529704

• Catalog number
  9438-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  N3-[2-[[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine
• Description
  SCH-529074 is a small molecule activator of mutant p53. It binds specifically to the p53 DBD (DNA binding domain) in a saturable manner with an affinity of 1-2 µM. Binding restores wild type function to many oncogenic mutant forms of p53. SCH-529074 reactivates mutant p53 by acting as a chaperone. In addition to reactivating mutant p53, SCH-529074 binding inhibits ubiquitination of p53 by HDM2.
• CAS Number
  922150-11-6
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₁H₃₆Cl₂N₆
• Molecular Weight
  563.56
• Cell Permeable
  Yes
• Purity
  ≥98%
• Solubilities
  DMSO (>40 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  An activator of mutant p53
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  12001922
• PubChem CID Link
• SMILES
  CN(C)CCCNC1=NC(=NC2=CC=CC=C21)CN3CCN(CC3)C(C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
• InChi
  InChI=1S/C31H36Cl2N6/c1-37(2)17-5-16-34-31-27-6-3-4-7-28(27)35-29(36-31)22-38-18-20-39(21-19-38)30(23-8-12-25(32)13-9-23)24-10-14-26(33)15-11-24/h3-4,6-15,30H,5,16-22H2,1-2H3,(H,34,35,36)
• InChi Key
  NCAJLQDPTZBGJV-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  SCH-529704  
• Gene symbol
  NF2
• Short name
  SCH-529704
• Alternative name
  SCH-529704

Gene info

• Identity
  HGNC:7773
• Gene
  NF2
• Long gene name
  NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
• Synonyms gene name
  • neurofibromin 2 (bilateral acoustic neuroma)
  • neurofibromin 2 (merlin)
• Synonyms
  • merlin
  • ACN
  • SCH
  • BANF
  • merlin-1
• Synonyms name
  • moesin-ezrin-radixin like
  • schwannomin
  • bilateral acoustic neurofibromatosis
• GenBank acession
  • L11353
• Locus
  22q12.2
• Discovery year
  1992-01-01
• Entrez gene record
  4771
• Pubmed identfication
  • 10591208
• RefSeq identity
  • NM_000268
• Classification
  • FERM domain containing
  • A-kinase anchoring proteins
• VEGA ID
  OTTHUMG00000030727
• Locus Specific Databases
  • Neurofibromatosis 2 (NF2) mutation database
  • LRG_511

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