AZ-6102

• Catalog number
  B1200-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  2-(4-(6-((3R,5S)-3,5-dimethylpiperazin-1-yl)-4-methylpyridin-3-yl)phenyl)-7-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
• Description
  AZ-6102 is a potent TNKS1/2 inhibitor (Tankyrase) that displays >100-fold selectivity against other poly (ADP-ribose) polymerase (PARP) family enzymes and inhibits Wnt pathway with IC₅₀ value of 5 nM in DLD-1 cells. Inhibition of the PARP catalytic domain of the tankyrases is known to inhibit the Wnt pathway via increased stabilization of Axin. Wnt pathway plays important role in cancer, tissue homeostasis; germline mutations of various Wnt pathway components as Axin can lead to oncogenesis.
• CAS Number
  1645286-75-4
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₅H₂₈N₆O
• Molecular Weight
  428.54
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO(>20 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent TNKS1/2 inhibitor (Tankyrase) having greater selectivity against PARP family enzymes and inhibits Wnt pathway
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  91663328
• PubChem CID Link
• SMILES
  CC1CN(CC(N1)C)C2=NC=C(C(=C2)C)C3=CC=C(C=C3)C4=NC(=O)C5=C(N4)N(C=C5)C
• InChi
  InChI=1S/C25H28N6O/c1-15-11-22(31-13-16(2)27-17(3)14-31)26-12-21(15)18-5-7-19(8-6-18)23-28-24-20(25(32)29-23)9-10-30(24)4/h5-12,16-17,27H,13-14H2,1-4H3,(H,28,29,32)/t16-,17+
• InChi Key
  WCPTUQOMNJBIET-CALCHBBNSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  AZ-6102  
• Short name
  AZ-6102
• Alternative name
  AZ-6102

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