LY364947

• Catalog number
  2646-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-quinoline; HTS 466284
• Description
  LY364947 is a selective inhibitor of TGF-β RI (TGFR-I, TβR-I, ALK-5), with an IC₅₀ value of 59 nM. LY364947 only weakly inhibits TGF-β RII (IC₅₀ = 400 nM), p38 MAPK (IC₅₀ = 740 nM), and mixed lineage kinase-7 (MLK-7; IC₅₀ = 1,400 nM).It inhibits TGF-β-induced cell growth (IC₅₀ = 89 nM) in NIH 3T3 mouse fibroblasts and TGF-β-directed Smad phosphorylation, synthesis of fibronectin, PAI-1 and uPA protein, and matrigel invasion in MDA-MB-231 cells.
• CAS Number
  396129-53-6
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₇H₁₂N₄
• Molecular Weight
  272.31
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~ 25 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A selective TGF-β RI (ALK-5) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  48 months
• PubChem CID
  447966
• PubChem CID Link
• SMILES
  C1=CC=C2C(=C1)C(=CC=N2)C3=C(NN=C3)C4=CC=CC=N4
• InChi
  InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21)
• InChi Key
  IBCXZJCWDGCXQT-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  LY364947  
• Short name
  LY364947
• Alternative name
  LY364947

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