5’-Deoxy-5’-methylthioadenosine
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Catalog number
B1053-10
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Price
Please ask
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Size
10 mg
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Alternative_name
5'-S-methyl-5'-thio-adenosine; Methylthioadenosine; MTA; NSC 335422; Vitamil L2
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Description
5'-Deoxy-5'-methylthioadenosine (MTA) is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine. Acts as a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 μM for A1, A2A, A2B, and A3, respectively). At higher concentrations, MTA inhibits several enzymes, including protein carboxylmethyltransferase (Ki = 41 μM), S-adenosylhomocysteine hydrolase, SET methyltransferases, and spermidine and spermine synthases.
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CAS Number
2457-80-9
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₁₁H₁₅N₅O₃S
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Molecular Weight
297.3
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Cell Permeable
Yes
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Purity
≥98%
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Solubilities
DMSO (~25 mg/ml)
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Handling
Protect from air and light
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Tag Line
A methyltransferase inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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MDL Number
MFCD00010533
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PubChem CID
439176
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SMILES
CSCC1C(C(C(O1)N2C=NC3=C2N=CN=C3N)O)O
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InChi
InChI=1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1
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InChi Key
WUUGFSXJNOTRMR-IOSLPCCCSA-N
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MSDS Available
Yes
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