WAY-600

Alternative_name

WAY-600; WAY600; WAY600; 4-[6-(1H-indol-5-yl)-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-4-yl]morpholine
Description

WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold).
CAS Number

1062159-35-6
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₈H₃₀N₈O
Molecular Weight

494.59
Cell Permeable

Yes
Purity

>98%
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A potent, ATP-competitive and selective inhibitor of mTOR
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD22419019
PubChem CID

25229526
PubChem CID Link
SMILES

C1CN(CCC1N2C3=C(C=N2)C(=NC(=N3)C4=CC5=C(C=C4)NC=C5)N6CCOCC6)CC7=CN=CC=C7
InChi

InChI=1S/C28H30N8O/c1-2-20(17-29-8-1)19-34-10-6-23(7-11-34)36-28-24(18-31-36)27(35-12-14-37-15-13-35)32-26(33-28)22-3-4-25-21(16-22)5-9-30-25/h1-5,8-9,16-18,23,30H,6-7,10-15,19H2
InChi Key

FPEIJQLXFHKLJV-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes