BTK Inhibitor, CNX-774

• Catalog number
  2600-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide
• Description
  CNX-774 is a potent, irreversible BTK inhibitor (IC₅₀ < 1 nM). CNX-774 is highly selective for BTK, and forms a ligand-directed covalent bond with the Cys-481 residue within the ATP binding site of the enzyme.
• CAS Number
  1202759-32-7
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₂₆H₂₂FN₇O₃
• Molecular Weight
  499.5
• Cell Permeable
  Yes
• Purity
  >98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A potent BTK inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• PubChem CID
  59174579
• PubChem CID Link
• SMILES
  CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)F
• InChi
  InChI=1S/C26H22FN7O3/c1-3-23(35)31-17-5-4-6-18(13-17)32-24-21(27)15-30-26(34-24)33-16-7-9-19(10-8-16)37-20-11-12-29-22(14-20)25(36)28-2/h3-15H,1H2,2H3,(H,28,36)(H,31,35)(H2,30,32,33,34)
• InChi Key
  VVLHQJDAUIPZFH-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  BTK   Inhibitor   CNX-774  
• Gene symbol
  CANX, BTK
• Short name
  BTK Inhibitor, CNX-774
• Alternative name
  Bruton agammaglobulinemia tyrosine kinase suppressor, CNX-774
• Alternative to gene target
  Bruton agammaglobulinemia tyrosine kinase, AGMX1 and AT and ATK and BPK and IMD1 and PSCTK1 and XLA, BTK and IDBG-79651 and ENSG00000010671 and 695, phosphatidylinositol-3, nuclei, Btk and IDBG-171427 and ENSMUSG00000031264 and 12229, BTK and IDBG-633447 and ENSBTAG00000019250 and 533459

Gene info

• Identity
  HGNC:1473
• Gene
  CANX
• Long gene name
  calnexin
• Synonyms
  • CNX
  • IP90
  • P90
• Synonyms name
  • major histocompatibility complex class I antigen-binding protein p88
• GenBank acession
  • L18887
• Locus
  5q35.3
• Discovery year
  1993-07-12
• Entrez gene record
  821
• Pubmed identfication
  • 1326756
  • 8136357
• RefSeq identity
  • NM_001024649
• VEGA ID
  OTTHUMG00000130910

Gene info

• Identity
  HGNC:1133
• Gene
  BTK
• Long gene name
  Bruton tyrosine kinase
• Synonyms gene
  • AGMX1
  • IMD1
• Synonyms gene name
  • Bruton agammaglobulinemia tyrosine kinase
• Synonyms
  • ATK
  • XLA
  • PSCTK1
• Synonyms name
  • Bruton's tyrosine kinase
• GenBank acession
  • AK057105
• Locus
  Xq22.1
• Discovery year
  1986-01-01
• Entrez gene record
  695
• Pubmed identfication
  • 8380905
• RefSeq identity
  • NM_000061
• Classification
  • Tec family tyrosine kinases
  • SH2 domain containing
  • Pleckstrin homology domain containing
• VEGA ID
  OTTHUMG00000022022
• Locus Specific Databases
  • BTK base: Mutation registry for X-linked agammaglobulinemia
  • Global Variome shared LOVD
  • LRG_128

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