ORY-1001

• Catalog number
  B1957-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  N1-((1R,2S)-2-phenylcyclopropyl)cyclohexane-1,4-diamine, dihydrochloride; RG-6016
• Description
  ORY-1001 is a potent and selective inhibitor of LSD1 (IC₅₀ < 20 nM). It targets acute myeloid leukemia (AML) stem cells and significantly reduces tumor cell load while increasing survival time in mouse models of AML. ORY-1001 is in clinical trials for cancer treatment.
• CAS Number
  1431326-61-2
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₅H₂₄Cl₂N₂
• Molecular Weight
  303.27
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~7 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent and selective LSD1 inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  71664305
• PubChem CID Link
• SMILES
  C1CC(CCC1N)NC2CC2C3=CC=CC=C3.Cl.Cl
• InChi
  InChI=1S/C15H22N2.2ClH/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11;;/h1-5,12-15,17H,6-10,16H2;2*1H/t12?,13?,14-,15+;;/m0../s1
• InChi Key
  UCINOBZMLCREGM-RNNUGBGQSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  ORY-1001  
• Gene symbol
  IGKV1ORY-1
• Short name
  ORY-1001
• Alternative name
  ORY-1001

Gene info

• Identity
  HGNC:37729
• Gene
  IGKV1ORY-1
• Long gene name
  immunoglobulin kappa variable 1/ORY-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin kappa variable 1/ORY-1 pseudogene
• Synonyms
  • IGKV1/ORY-1
• Locus
  Yq11.21
• Discovery year
  2010-02-10
• Entrez gene record
  439957
• Classification
  • Immunoglobulin kappa (IGK) orphons

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