β-Glycyrrhetinic acid

• Catalog number
  9586-1G
• Price
  Please ask
• Size
  1 g

• Alternative_name
  3β-Hydroxy-11-oxo-18β,20β-olean-12-en-29-oic acid, Enoxolone; STX352; GM1658; NSC 35347
• Description
  β-Glycyrrhetinic acid is a major metabolite of glycyrrhizin, one of the main constituents of licorice. It inhibits 15-PGDH (15-hydroxyprostaglandin dehydrogenase) leading to increased prostaglandin concentration in the digestive system. Displays anti-ulcerative, anti-inflammatory, and immunomodulatory properties. In addition, β-Glycyrrhetinic acid inhibits mammalian DNA polymerases α, γ, κ, and λ with IC₅₀ values of 16.1, 19.3, 15.8, and 13.7 μM, respectively. Also protects liver against the toxic effect of chemotherapeutic alkylating agents via activation of Nrf2 (NF-E2-related factor-2) and PPARγ.
• CAS Number
  471-53-4
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₀H₄₆O₄
• Molecular Weight
  470.68
• Cell Permeable
  Yes
• Purity
  ≥97% by titration
• Solubilities
  DMSO (>15 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent 15-PGDH (15-hydroxy prostaglandin dehydrogenase) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD00003706
• PubChem CID
  10114
• PubChem CID Link
• SMILES
  CC1(C2CCC3(C(C2(CCC1O)C)C(=O)C=C4C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C
• InChi
  InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1
• InChi Key
  MPDGHEJMBKOTSU-YKLVYJNSSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  β-Glycyrrhetinic   acid  
• Short name
  β-Glycyrrhetinic acid
• Alternative name
  β-Glycyrrhetinic acid

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