Torin 1

• Catalog number
  2273-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  1-[4-[4-(1-Oxopropyl)-1-piperazinyl­]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benz­o[h]-1,6-naphthyridin-2(1H)-one
• Description
  A potent, selective and ATP-competitive mTOR inhibitor, with IC₅₀ values of 2 and 10 nM for mTORC1 and mTORC2 respectively; Torin1 displays 1000-fold selectivity for mTOR over PI3K (EC₅₀ = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases.
• CAS Number
  1222998-36-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₅H₂₈F₃N₅O₂
• Molecular Weight
  607.62
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~20 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A potent mTOR inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD18782653
• PubChem CID
  49836027
• PubChem CID Link
• SMILES
  CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F
• InChi
  InChI=1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36,37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12,17-21H,2,13-16H2,1H3
• InChi Key
  AKCRNFFTGXBONI-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Torin  
• Gene symbol
  PRDX2
• Short name
  Torin 1
• Alternative name
  Torin 1

Gene info

• Identity
  HGNC:9353
• Gene
  PRDX2
• Long gene name
  peroxiredoxin 2
• Synonyms gene
  • TDPX1
• Synonyms
  • PRP
  • NKEFB
  • TSA
  • PRXII
  • PRX2
  • MGC4104
• Synonyms name
  • thioredoxin-dependent peroxide reductase 1
  • thiol-specific antioxidant 1
  • natural killer-enhancing factor B
  • thioredoxin peroxidase 1
  • torin
• Locus
  19p13.13
• Discovery year
  1995-07-06
• Entrez gene record
  7001
• Pubmed identfication
  • 7607688
• RefSeq identity
  • NM_005809
• Classification
  • Peroxiredoxins
• VEGA ID
  OTTHUMG00000134285

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