BMX-IN-1

Alternative_name

N-[5-[9-[4-(methanesulfonamido)phenyl]-2-oxobenzo[h][1,6]naphthyridin-1-yl]-2-methylphenyl]prop-2-enamide
Description

BMX-IN-1 is a highly selective and potent irreversible inhibitor of BMX kinase.
CAS Number

1431525-23-3
Structure Available

Yes
Salt Form

No
Molecular Formula

C29H24N4O4S
Molecular Weight

524.59
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>5.3 mg/ml)
Handling

Protect from air and light
Tag Line

A highly selective and potent irreversible inhibitor of BMX kinase
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

71576693
PubChem CID Link
SMILES

CC1=C(C=C(C=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CC=C(C=C5)NS(=O)(=O)C)NC(=O)C=C
InChi

1S/C29H24N4O4S/c1-4-27(34)31-26-16-23(12-5-18(26)2)33-28(35)14-9-21-17-30-25-13-8-20(15-24(25)29(21)33)19-6-10-22(11-7-19)32-38(3,36)37/h4-17,32H,1H2,2-3H3,(H,31,34)
InChi Key

SFMJNHNUOVADRW-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Gene target

BMX-IN-1
Gene symbol

BMX, CD44, IGHVII-1-1, MIR1-1, TRUND-NNN8-1, TRUND-NNN7-1, IGKV1OR2-1, MIR101-1, MIR1289-1, MIR16-1
Short name

BMX-IN-1
Alternative name

BMX-IN-1

Identity

HGNC:1079
Gene

BMX
Long gene name

BMX non-receptor tyrosine kinase
Synonyms
- ETK
- PSCTK3
Synonyms name
- BTK-like on X chromosome
GenBank acession
- AF045459
Locus

Xp22.2
Discovery year

1995-07-11
Entrez gene record

660
Pubmed identfication
- 7970727
RefSeq identity
- NM_001721
Classification
- Tec family tyrosine kinases
- SH2 domain containing
- Pleckstrin homology domain containing
VEGA ID

OTTHUMG00000021180
Locus Specific Databases
- Global Variome shared LOVD

Identity

HGNC:1681
Gene

CD44
Long gene name

CD44 molecule (Indian blood group)
Synonyms gene
- MIC4
- MDU2
- MDU3
Synonyms gene name
- CD44 antigen (homing function and Indian blood group system)
Synonyms
- IN
- MC56
- Pgp1
- CD44R
- HCELL
- CSPG8
Synonyms name
- hematopoietic cell E- and L-selectin ligand
- chondroitin sulfate proteoglycan 8
GenBank acession
- M59040
Locus

11p13
Discovery year

1989-06-30
Entrez gene record

960
Pubmed identfication
- 2454887
RefSeq identity
- NM_000610
Classification
- Proteoglycans
- Blood group antigens
- CD molecules
VEGA ID

OTTHUMG00000044388
Locus Specific Databases
- LRG_815

Identity

HGNC:5670
Gene

IGHVII-1-1
Long gene name

immunoglobulin heavy variable (II)-1-1 (pseudogene)
Synonyms gene name
- immunoglobulin heavy variable (II)-1-1
- immunoglobulin heavy variable (II)-1-1 pseudogene
Synonyms
- IGHV(II)-1-1
GenBank acession
- AB019441
Locus

14q32.33
Discovery year

2000-04-17
Entrez gene record

28377
RefSeq identity
- NG_001019
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000152325

Identity

HGNC:5760
Gene

IGKV1OR2-1
Long gene name

immunoglobulin kappa variable 1/OR2-1 (pseudogene)
Synonyms gene
- IGKVPZ1
- IGKV1OR-1
Synonyms gene name
- immunoglobulin kappa variable 1/OR-1
- immunoglobulin kappa variable 1/OR-1 pseudogene
- immunoglobulin kappa variable 1/OR-1 (pseudogene)
Synonyms
- IGKV1/OR-1
- IGKV1/OR2-1
GenBank acession
- Z12367
Locus

2p11.1
Discovery year

2000-04-18
Entrez gene record

3531
Pubmed identfication
- 2853098
Classification
- Immunoglobulin kappa (IGK) orphons
VEGA ID

OTTHUMG00000155081