NKL 22 (MDK-4154)

Alternative_name

N1-(2-aminophenyl)-N7-phenylheptanediamide
Description

NKL 22 (also known as MDK-4154) is a cell-permeable compound that acts as a FXN- (frataxin gene) specific HDAC (histone deacetylase) inhibitor. It reverses the silencing of FXN transcription in FRDA (Friedreich’s ataxia) cells due to hypoacetylation of histones H3 and H4 by increasing acetylation at H3K14, H4K12, and H4K5 without much acetylation on H3K9, H4K8 and H4K16.
CAS Number

537034-15-4
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₉H₂₃N₃O₂
Molecular Weight

325.4
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (100 mg/ml)
Handling

Protect from air and light
Tag Line

A histone deacetylase (HDAC) inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

9543539
PubChem CID Link
SMILES

C1=CC=C(C=C1)NC(=O)CCCCCC(=O)NC2=CC=CC=C2N
InChi

1S/C19H23N3O2/c20-16-11-7-8-12-17(16)22-19(24)14-6-2-5-13-18(23)21-15-9-3-1-4-10-15/h1,3-4,7-12H,2,5-6,13-14,20H2,(H,21,23)(H,22,24)
InChi Key

ZAIULUYKQLVQFH-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes