Z-IETD-FMK

Alternative_name

Z-IETD-FMK, Z-IETD-fluoromethylketone, Caspase-8 Inhibitor (fluoromethylketone)
Description

A synthetic peptide that irreversibly inhibits FLICE and related protease/caspase activity and blocks apoptosis. IETD is the specific recognition sequence found in CPP32 proenzyme. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups.)
Structure Available

No
Peptide sequence

Z-Ile-Glu(OMe)-Thr-Asp(OMe)-FMK
Salt Form

No
Molecular Formula

C₃₀H₄₃FN₄O₁₁
Molecular Weight

654.7
Cell Permeable

Yes
Purity

Single spot by TLC
Solubilities

DMSO (20 mM)
Handling

Protect from light and moisture
Tag Line

A caspase-8 inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

12 months
MDL Number

MFCD01861686
PubChem CID

44135212
PubChem CID Link
SMILES

CCC(C)C(C(=O)NC(CCC(=O)OC)C(=O)NC(C(C)O)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O) OCC1=CC=CC=C1
InChi

InChI=1S/C30H43FN4O11/c1-6-17(2)25(35-30(43)46-16-19-10-8-7-9-11-19)28 (41)32-20(12-13-23(38)44-4)27(40)34-26(18(3)36)29(42)33-21(22(37)15-31) 14-24(39)45-5/h7-11,17-18,20-21,25-26,36H,6,12-16H2,1-5H3,(H,32,41)(H, 33,42)(H,34,40)(H,35,43)
InChi Key

PHLCQASLWHYEMX-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:9544
Gene

PSMB7
Long gene name

proteasome 20S subunit beta 7
Synonyms gene name
- proteasome (prosome, macropain) subunit, beta type, 7
- proteasome subunit beta 7
Synonyms
- Z
Synonyms name
- proteasome subunit β2
GenBank acession
- AJ420455
Locus

9q33.3
Discovery year

1995-11-22
Entrez gene record

5695
Pubmed identfication
- 8811196
RefSeq identity
- NM_002799
Classification
- Proteasome
VEGA ID

OTTHUMG00000021042