Fasudil, Monohydrochloride
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Catalog number
1787-10
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Price
Please ask
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Size
10 mg
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Alternative_name
1-(5-Isoquinolinesulfonyl)homopiperazine, Monohydrochloride Salt; HA-1077, Monohydrochloride; AT-877
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Description
A cell-permeable Ca²⁺ antagonist and vasodilator. Inhibits protein kinase A (Ki = 1.6 µM), protein kinase G (Ki = 1.6 µM), myosin light chain kinase (Ki = 36 µM) and Rho kinase (ROCK; IC₅₀ = 10.7 µM. Fasudil also mobilizes adult neural stem cells in vivo.
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CAS Number
105628-07-7
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₁₄H₁₇N₃O₂S•HCl
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Molecular Weight
327.83
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Cell Permeable
Yes
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Purity
≥99% by HPLC
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Solubilities
Water (175 mg/ml) or DMSO (10 mg/ml)
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Handling
Protect from air and moisture
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Tag Line
A Rho kinase (ROCK) inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
48 months
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MDL Number
MFCD00943198
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PubChem CID
163751
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SMILES
C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl
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InChi
InChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H
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InChi Key
LFVPBERIVUNMGV-UHFFFAOYSA-N
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MSDS Available
Yes
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Gene target
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Short name
Fasudil, Monohydrochloride
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Alternative name
Fasudil, Monohydrochloride
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Product images
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