L-755,507

• Catalog number
  B1116-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide
• Description
  L-755,507 is a partial agonist of β3-adrenergic receptors (EC₅₀ = 0.43 nM). It displays >440-fold selectivity for β3- over β1- and β2-adrenoceptors (EC₅₀s = 580 and >10,000 nM, respectively). Enhances CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs).
• CAS Number
  159182-43-1
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₀H₄₀N₄O₆S
• Molecular Weight
  584.73
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>50 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A partial agonist of β3-adrenergic receptors and a HDR enhancer
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  9829836
• PubChem CID Link
• SMILES
  CCCCCCNC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
• InChi
  InChI=1S/C30H40N4O6S/c1-2-3-4-5-19-32-30(37)33-24-10-16-29(17-11-24)41(38,39)34-25-8-6-23(7-9-25)18-20-31-21-27(36)22-40-28-14-12-26(35)13-15-28/h6-17,27,31,34-36H,2-5,18-22H2,1H3,(H2,32,33,37)/t27-/m0/s1
• InChi Key
  NYYJKMXNVNFOFQ-MHZLTWQESA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  L-755   507  
• Gene symbol
  CPT1A, POM121L2, L3MBTL2, CLDN10, RPL32P1, FABP1, COX7A2, NFIA, MAS1L, ANP32E
• Short name
  L-755 507
• Alternative name
  L-755,507

Gene info

• Identity
  HGNC:2328
• Gene
  CPT1A
• Long gene name
  carnitine palmitoyltransferase 1A
• Synonyms gene
  • CPT1
• Synonyms gene name
  • carnitine palmitoyltransferase 1A (liver)
• Synonyms
  • CPT1-L
  • L-CPT1
• GenBank acession
  • L39211
• Locus
  11q13.3
• Discovery year
  1995-05-30
• Entrez gene record
  1374
• Pubmed identfication
  • 7892212
  • 9070950
• RefSeq identity
  • NM_001876
• VEGA ID
  OTTHUMG00000167892

Gene info

• Identity
  HGNC:13973
• Gene
  POM121L2
• Long gene name
  POM121 transmembrane nucleoporin like 2
• Synonyms gene name
  • POM121 membrane glycoprotein-like 2 (rat)
  • POM121 membrane glycoprotein-like 2
  • POM121 transmembrane nucleoporin-like 2
• Synonyms
  • POM121-L
• GenBank acession
  • AL021808
• Locus
  6p22.1
• Discovery year
  2001-07-20
• Entrez gene record
  94026
• RefSeq identity
  • NM_033482
• VEGA ID
  OTTHUMG00000014475

Gene info

• Identity
  HGNC:18594
• Gene
  L3MBTL2
• Long gene name
  L3MBTL histone methyl-lysine binding protein 2
• Synonyms gene name
  • l(3)mbt-like 2 (Drosophila)
  • L3MBTL2, polycomb repressive complex 1 subunit
• Synonyms
  • H-l(3)mbt-l
  • DKFZP761I141
  • dJ756G23.3
• GenBank acession
  • AJ305226
• Locus
  22q13.2
• Discovery year
  2002-04-29
• Entrez gene record
  83746
• Pubmed identfication
  • 11682070
  • 21596310
• RefSeq identity
  • NM_031488
• Classification
  • MBT domain containing
• VEGA ID
  OTTHUMG00000150942

Gene info

• Identity
  HGNC:2033
• Gene
  CLDN10
• Long gene name
  claudin 10
• Synonyms
  • OSP-L
  • CPETRL3
• GenBank acession
  • U89916
• Locus
  13q32.1
• Discovery year
  1999-01-22
• Entrez gene record
  9071
• Pubmed identfication
  • 18025272
• RefSeq identity
  • NM_006984
• Classification
  • Claudins
• VEGA ID
  OTTHUMG00000017217

Gene info

• Identity
  HGNC:10339
• Gene
  RPL32P1
• Long gene name
  ribosomal protein L32 pseudogene 1
• Synonyms gene
  • RPL32P
• Synonyms gene name
  • ribosomal protein L32 pseudogene
• Synonyms
  • RPL32-L
• GenBank acession
  • X02228
• Locus
  6p21.32
• Discovery year
  2009-03-01
• Entrez gene record
  6163
• Pubmed identfication
  • 3866218
  • 19123937
• RefSeq identity
  • NG_000869
• VEGA ID
  OTTHUMG00000031191

Gene info

• Identity
  HGNC:3555
• Gene
  FABP1
• Long gene name
  fatty acid binding protein 1
• Synonyms gene name
  • fatty acid binding protein 1, liver
• Synonyms
  • L-FABP
• GenBank acession
  • M10617
• Locus
  2p11.2
• Discovery year
  2001-06-22
• Entrez gene record
  2168
• Pubmed identfication
  • 3012800
  • 17698986
• RefSeq identity
  • NM_001443
• Classification
  • Fatty acid binding protein family
• VEGA ID
  OTTHUMG00000130312

Gene info

• Identity
  HGNC:2288
• Gene
  COX7A2
• Long gene name
  cytochrome c oxidase subunit 7A2
• Synonyms gene name
  • cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
• Synonyms
  • COXVIIa-L
  • COX7AL
• GenBank acession
  • X15822
• Locus
  6q14.1
• Discovery year
  1992-11-25
• Entrez gene record
  1347
• Pubmed identfication
  • 1327965
  • 9202412
• RefSeq identity
  • NM_001865
• Classification
  • Mitochondrial complex IV: cytochrome c oxidase subunits
• VEGA ID
  OTTHUMG00000015049

Gene info

• Identity
  HGNC:7784
• Gene
  NFIA
• Long gene name
  nuclear factor I A
• Synonyms gene name
  • nuclear factor I/A
• Synonyms
  • NFI-L
  • KIAA1439
• GenBank acession
  • U07809
• Locus
  1p31.3
• Discovery year
  1995-03-09
• Entrez gene record
  4774
• Pubmed identfication
  • 7590749
• RefSeq identity
  • NM_005595
• Classification
  • Nuclear factor I family
• VEGA ID
  OTTHUMG00000008618

Gene info

• Identity
  HGNC:13961
• Gene
  MAS1L
• Long gene name
  MAS1 proto-oncogene like, G protein-coupled receptor
• Synonyms gene name
  • MAS1 oncogene-like
• Synonyms
  • MAS-L
  • MRG
  • dJ994E9.2
• GenBank acession
  • S78653
• Locus
  6p22.1
• Discovery year
  2002-11-18
• Entrez gene record
  116511
• RefSeq identity
  • NM_052967
• Classification
  • G protein-coupled receptors, Class A orphans
• VEGA ID
  OTTHUMG00000031089

Gene info

• Identity
  HGNC:16673
• Gene
  ANP32E
• Long gene name
  acidic nuclear phosphoprotein 32 family member E
• Synonyms gene name
  • acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
• Synonyms
  • LANPL
  • MGC5350
  • LANP-L
• GenBank acession
  • AK092672
• Locus
  1q21.2
• Discovery year
  2003-04-15
• Entrez gene record
  81611
• Pubmed identfication
  • 12438741
• RefSeq identity
  • NM_030920
• Classification
  • ANP32 acidic nuclear phosphoproteins
• VEGA ID
  OTTHUMG00000012547

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