EPZ004777

• Catalog number
  2381-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  1-(3-((((2R,3S,4R,5R)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea
• Description
  A potent and selective DOT1L inhibitor. Treatment of leukemic cells with EPZ004777 results in selective killing of those cells bearing the MLL (mixed lineage leukemia) gene translocation, with little effect on non-MLL-translocated cells.
• CAS Number
  1338466-77-5
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₈H₄₁N₇O₄
• Molecular Weight
  539.67
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from light and air
• Tag Line
  A potent DOT1L inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  70702060
• PubChem CID Link
• SMILES
  CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2C(C(C(O2)N3C=CC4=C3N=CN=C4N)O)O
• InChi
  InChI=1S/C28H41N7O4/c1-17(2)34(13-6-12-30-27(38)33-19-9-7-18(8-10-19)28(3,4)5)15-21-22(36)23(37)26(39-21)35-14-11-20-24(29)31-16-32-25(20)35/h7-11,14,16-17,21-23,26,36-37H,6,12-13,15H2,1-5H3,(H2,29,31,32)(H2,30,33,38)/t21?,22-,23-,26?/m1/s1
• InChi Key
  WXRGFPHDRFQODR-QQNJPBSNSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  EPZ004777  
• Short name
  EPZ004777
• Alternative name
  EPZ004777

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