Human CellExp™ B7-1 / CD80, mouse recombinant

• Catalog number
  P1075-50
• Price
  Please ask
• Size
  50 µg

• Synonyms
  CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB8
• Alternative_names
  CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB8
• Description
  Plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages
• Recombinant
  Yes
• Source
  HEK 293 cells
• Purity by SDS PAGE
  >95%
• Assay
  SDS-PAGE
• Endotoxin Level
  < 1 EU/ug
• Activity Specifications test method
  Measured by its binding ability in a functional ELISA
• Biological activity
  Immobilized Mouse B7-1, His Tag at 2ug/Ml (100 uL/well) can bind Mouse CTLA-4, Fc Tag with a linear range of 0.12-0.5 ng/mL.
• Binding Capacity
  Immobilized Mouse B7-1, His Tag at 2ug/Ml (100 uL/well) can bind Mouse CTLA-4, Fc Tag with a linear range of 0.12-0.5 ng/mL.
• Molecular Weight
  25.6 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized
• Physical form description
  Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.
• Reconstitution Instructions
  Reconstitute in sterile deionized water to a concentration of 50 ug/ml.
• Background Information
  B7-1 and B7-2, together with their receptors CD28 and CTLA­4, constitute one of the dominant co-stimulatory pathways that regulate T­ and B­cell responses. Although both CTLA­4 and CD28 can bind to the same ligands, CTLA­4 binds to B7­1 and B7­2 with a 20 ­ 100 fold higher affinity than CD28 and is involved in the down­regulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA- 4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CellExp™   B7-1   CD80  
• Gene symbol
  CD80, HHLA2, RNY4P2, LRRC23, PCDHGB7, NCR3LG1, CD274, CD86, TLX1NB, CD276
• Short name
  CellExp™ B7-1 / CD80, mouse recombinant
• Technique
  Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Host
  mouse
• Species
  Humans, Mouses
• Alternative name
  H. sapiens CellExp™ B7-1 / CD80 molecule, mouse Rec.
• Alternative technique
  rec, murine
• Alternative to gene target
  CD80 molecule, B7 and B7-1 and B7.1 and BB1 and CD28LG and CD28LG1 and LAB7, CD80 and IDBG-51287 and ENSG00000121594 and 941, coreceptor activity, Cell surfaces, Cd80 and IDBG-160288 and ENSMUSG00000075122 and 12519, BT.27986 and IDBG-632750 and ENSBTAG00000018059 and 407131

Gene info

• Identity
  HGNC:1700
• Gene
  CD80
• Long gene name
  CD80 molecule
• Synonyms gene
  • CD28LG
  • CD28LG1
• Synonyms gene name
  • CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
  • CD80 molecule
• Synonyms
  • B7.1
  • B7-1
• Synonyms name
  • B-lymphocyte activation antigen B7
• Locus
  3q13.33
• Discovery year
  1993-12-14
• Entrez gene record
  941
• Pubmed identfication
  • 1370389
• RefSeq identity
  • NM_005191
• Classification
  • B7 family
  • CD molecules
  • C2-set domain containing
  • V-set domain containing
• VEGA ID
  OTTHUMG00000159419

Gene info

• Identity
  HGNC:4905
• Gene
  HHLA2
• Long gene name
  HERV-H LTR-associating 2
• Synonyms
  • B7H7
  • B7-H5
  • B7y
  • B7-H7
• GenBank acession
  • AF126162
• Locus
  3q13.13
• Discovery year
  1999-09-07
• Entrez gene record
  11148
• Pubmed identfication
  • 10444326
  • 23784006
  • 22488247
• RefSeq identity
  • NM_007072
• Classification
  • C1-set domain containing
  • V-set domain containing
  • B7 family
• VEGA ID
  OTTHUMG00000159224

Gene info

• Identity
  HGNC:10246
• Gene
  RNY4P2
• Long gene name
  RNY4 pseudogene 2
• Synonyms gene name
  • RNA, Y4 small cytoplasmic (associated with Ro protein) pseudogene 2
  • RNA, Ro-associated Y4 pseudogene 2
• Synonyms
  • hY4.B7
• GenBank acession
  • M77130
• Locus
  17q21.31
• Discovery year
  1993-08-25
• Entrez gene record
  6088
• RefSeq identity
  • NG_005037

Gene info

• Identity
  HGNC:19138
• Gene
  LRRC23
• Long gene name
  leucine rich repeat containing 23
• Synonyms
  • B7
  • LRPB7
• GenBank acession
  • BC014450
• Locus
  12p13.31
• Discovery year
  2006-01-24
• Entrez gene record
  10233
• Pubmed identfication
  • 11830501
  • 11826754
• RefSeq identity
  • NM_006992
• VEGA ID
  OTTHUMG00000156668

Gene info

• Identity
  HGNC:8714
• Gene
  PCDHGB7
• Long gene name
  protocadherin gamma subfamily B, 7
• Synonyms
  • ME6
  • PCDH-GAMMA-B7
• Synonyms name
  • cadherin ME6
• GenBank acession
  • AF152523
• Locus
  5q31.3
• Discovery year
  2000-06-28
• Entrez gene record
  56099
• Pubmed identfication
  • 10380929
• RefSeq identity
  • NM_018927
• Classification
  • Clustered protocadherins
• VEGA ID
  OTTHUMG00000164054

Gene info

• Identity
  HGNC:42400
• Gene
  NCR3LG1
• Long gene name
  natural killer cell cytotoxicity receptor 3 ligand 1
• Synonyms
  • DKFZp686O24166
  • B7-H6
• Synonyms name
  • B7 homolog 6
• Locus
  11p15.1
• Discovery year
  2012-04-12
• Entrez gene record
  374383
• Pubmed identfication
  • 19528259
• RefSeq identity
  • NM_001202439
• Classification
  • Receptor ligands
  • C1-set domain containing
  • B7 family
• VEGA ID
  OTTHUMG00000165913

Gene info

• Identity
  HGNC:17635
• Gene
  CD274
• Long gene name
  CD274 molecule
• Synonyms gene
  • PDCD1LG1
• Synonyms gene name
  • programmed cell death 1 ligand 1
  • CD274 antigen
• Synonyms
  • B7-H
  • B7H1
  • PD-L1
  • PDL1
  • B7-H1
• Synonyms name
  • B7 homolog 1
• GenBank acession
  • AF177937
• Locus
  9p24.1
• Discovery year
  2003-11-13
• Entrez gene record
  29126
• Pubmed identfication
  • 11015443
  • 10581077
• RefSeq identity
  • NM_014143
• Classification
  • Receptor ligands
  • C2-set domain containing
  • V-set domain containing
  • B7 family
  • CD molecules
• VEGA ID
  OTTHUMG00000019503

Gene info

• Identity
  HGNC:1705
• Gene
  CD86
• Long gene name
  CD86 molecule
• Synonyms gene
  • CD28LG2
• Synonyms gene name
  • CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
• Synonyms
  • B7.2
  • B7-2
• Synonyms name
  • B-lymphocyte antigen B7-2
• Locus
  3q13.33
• Discovery year
  1994-12-07
• Entrez gene record
  942
• Pubmed identfication
  • 7513726
• RefSeq identity
  • NM_006889
• Classification
  • B7 family
  • CD molecules
  • V-set domain containing
• VEGA ID
  OTTHUMG00000159482

Gene info

• Identity
  HGNC:37183
• Gene
  TLX1NB
• Long gene name
  TLX1 neighbor
• Synonyms
  • TD1
  • TDI
  • APT-B7
• Synonyms name
  • TLX1 divergent
• GenBank acession
  • BC019674
• Locus
  10q24.31
• Discovery year
  2009-08-14
• Entrez gene record
  100038246
• Pubmed identfication
  • 17303350
• RefSeq identity
  • NR_130722
• Classification
  • Long non-coding RNAs with non-systematic symbols
• VEGA ID
  OTTHUMG00000018925

Gene info

• Identity
  HGNC:19137
• Gene
  CD276
• Long gene name
  CD276 molecule
• Synonyms gene name
  • CD276 antigen
• Synonyms
  • B7-H3
  • B7H3
  • B7RP-2
• GenBank acession
  • AF302102
• Locus
  15q24.1
• Discovery year
  2005-03-04
• Entrez gene record
  80381
• Pubmed identfication
  • 11224528
  • 12055244
• RefSeq identity
  • NM_025240
• Classification
  • C2-set domain containing
  • V-set domain containing
  • B7 family
  • CD molecules
• VEGA ID
  OTTHUMG00000137585

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