Human CellExp™ B7-H6, human recombinant
-
Catalog number
P1013-10
-
Price
Please ask
-
Size
10 µg
-
-
Synonyms
Natural cytotoxicity triggering receptor 3 ligand 1
-
Alternative_names
B7-H6, Natural cytotoxicity triggering receptor 3 ligand 1, B7H6, B7 homolog 6, NCR3LG1
-
Description
Triggers NCR3-dependent natural killer cell activation.
-
Recombinant
Yes
-
Source
HEK 293 cells
-
Purity by SDS PAGE
≥ 98%
-
Assay
SDS-PAGE
-
Endotoxin Level
< 5 EU/mg
-
Molecular Weight
80 kDa
-
Storage Temp
-20°C
-
Shipping
Gel pack
-
Shelf Life
12 months
-
Appearance
Lyophilized
-
Physical form description
Lyophilized from 0.2um-filtered solution in PBS.
-
Reconstitution Instructions
Reconstitute in 1X PBS to the desired protein concentration.
-
Background Information
B7-H6 is a glycosylated member of the B7 family of immune costimulatory proteins. Orthologs in mouse and rat have not been identified. The Ig-like V domain mediates 1:1 stoichiometric binding of B7-H6 to NKp30 expressed on NK cells. It does not show binding to NKp44, NKp46, or NKG2D. Ligation of NKp30 by B7-H6 induces NK cell activation and target cell cytolysis. B7-H6 is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, which is consistent with the detection of NKp30 binding sites on many tumors. The expression of NKp30 ligands on tumor cells correlates with tumor cell sensitivity to NKp30-dependent cell lysis.
-
Handling
Centrifuge the vial prior to opening.
-
Usage
For Research Use Only! Not to be used in humans
-
-
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
Additional source
Recombinants or rec. proteins
-
Group
recombinants
-
Gene target
-
Gene symbol
NCR3LG1, HHLA2, HMX1, RNY4P2, LRRC23, PCDHGB7, CD274, CD86, NME6, TLX1NB
-
Short name
CellExp™ B7-H6, recombinant
-
Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
-
Species
Humans
-
Alternative name
H. sapiens CellExp™ B7-H6, H. sapiens Rec.
-
Alternative technique
rec
-
Gene info
Gene info
-
Identity
-
Gene
-
Long gene name
HERV-H LTR-associating 2
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year
1999-09-07
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- C1-set domain containing
- V-set domain containing
- B7 family
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene name
H6 family homeobox 1
-
Synonyms gene name
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year
1994-12-19
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- NKL subclass homeoboxes and pseudogenes
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene name
RNY4 pseudogene 2
-
Synonyms gene name
- RNA, Y4 small cytoplasmic (associated with Ro protein) pseudogene 2
- RNA, Ro-associated Y4 pseudogene 2
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year
1993-08-25
-
Entrez gene record
-
RefSeq identity
Gene info
Gene info
Gene info
-
Identity
-
Gene
-
Long gene name
CD274 molecule
-
Synonyms gene
-
Synonyms gene name
- programmed cell death 1 ligand 1
- CD274 antigen
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year
2003-11-13
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Receptor ligands
- C2-set domain containing
- V-set domain containing
- B7 family
- CD molecules
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene name
CD86 molecule
-
Synonyms gene
-
Synonyms gene name
- CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
-
Synonyms
-
Synonyms name
-
Locus
-
Discovery year
1994-12-07
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- B7 family
- CD molecules
- V-set domain containing
-
VEGA ID
Gene info
Gene info
-
Identity
-
Gene
-
Long gene name
TLX1 neighbor
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year
2009-08-14
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Long non-coding RNAs with non-systematic symbols
-
VEGA ID
MeSH Data
-
Name
-
Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products
