FAAH Inhibitor, PF-622
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Catalog number1928-5
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PricePlease ask
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Size5 mg
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Alternative_nameN-Phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carboxamide
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DescriptionCell-permeable. A potent and irreversible FAAH (Fatty Acid Amide Hydrolase) inhibitor. Inhibits FAAH in a time-dependent manner by covalently modifying the enzyme's active site serine (IC₅₀ = 33 nM). It is highly selective for FAAH relative to other mammalian serine hydrolases.
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CAS Number898235-65-9
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₁H₂₂N₄O
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Molecular Weight346.43
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Cell PermeableYes
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Purity≥98% by TLC
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SolubilitiesDMSO (~25 mg/ml) or Ethanol (~ 3 mg/ml)
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HandlingProtect from light and air
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Tag LineA potent and irreversible FAAH (Fatty Acid Amide Hydrolase) inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID11515763
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SMILESC1CN(CCN1CC2=NC3=CC=CC=C3C=C2)C(=O)NC4=CC=CC=C4
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InChiInChI=1S/C21H22N4O/c26-21(23-18-7-2-1-3-8-18)25-14-12-24(13-15-25)16-19-11-10-17-6-4-5-9-20(17)22-19/h1-11H,12-16H2,(H,23,26)
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InChi KeySNTCRRMCALVGNL-UHFFFAOYSA-N
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MSDS AvailableYes
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolFAAH, FAAHP1, MIR622, FA2H, FAAH2
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Short nameFAAH Inhibitor, PF-622
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Alternative nameFAAH suppressor, PF-622
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Gene info
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Identity
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Gene
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Long gene namefatty acid amide hydrolase
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-01-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namefatty acid amide hydrolase pseudogene 1
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Synonyms gene
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Synonyms gene name
- long intergenic non-protein coding RNA 505
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Synonyms
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Locus
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Discovery year2014-06-05
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicroRNA 622
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Synonyms gene
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Synonyms
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Locus
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Discovery year2006-05-17
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNAs
Gene info
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Identity
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Gene
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Long gene namefatty acid 2-hydroxylase
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Synonyms gene
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Synonyms gene name
- fatty acid hydroxylase domain containing 1
- spastic paraplegia 35 (autosomal recessive)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2003-05-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Fatty acid hydroxylase domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namefatty acid amide hydrolase 2
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Synonyms gene
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Synonyms gene name
- amidase domain containing
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Synonyms
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GenBank acession
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Locus
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Discovery year2006-07-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
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Locus Specific Databases