RVX-208

Alternative_name

2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-4(3H)-quinazolinone
Description

RVX-208 is a potent inhibitor of BET bromodomains. It increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo.
CAS Number

1044870-39-4
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₀H₂₂N₂O₅
Molecular Weight

370.4
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (~ 50 mg/ml)
Handling

Protect from air and light
Tag Line

A potent BET bromodomain inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

24871506
PubChem CID Link
SMILES

CC1=CC(=CC(=C1OCCO)C)C2=NC(=O)C3=C(C=C(C=C3N2)OC)OC
InChi

InChI=1S/C20H22N2O5/c1-11-7-13(8-12(2)18(11)27-6-5-23)19-21-15-9-
InChi Key

NETXMUIMUZJUTB-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:8222
Gene

OR1P1
Long gene name

olfactory receptor family 1 subfamily P member 1 (gene/pseudogene)
Synonyms gene
- OR1P1P
Synonyms gene name
- olfactory receptor, family 1, subfamily P, member 1 pseudogene
- olfactory receptor, family 1, subfamily P, member 1 (gene/pseudogene)
Synonyms
- OR17-208
GenBank acession
- AF087927
Locus

17p13.3
Discovery year

1998-09-14
Entrez gene record

8391
Pubmed identfication
- 10673334
RefSeq identity
- NG_002153
Classification
- Olfactory receptors, family 1
VEGA ID

OTTHUMG00000177731