GLPG0634 Analog

Alternative_name

N-[5-[4-[(6-Cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxamide; GLP-0634
Description

GLPG0634 analog is a potent and selective JAK1 inhibitor with IC₅₀ values of 10, 28, 810, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
CAS Number

1206101-20-3
Structure Available

Yes
Molecular Formula

C₂₃H₁₈N₆O₂
Molecular Weight

410.44
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>40 mg/ml)
Handling

Protect from air and light
Tag Line

A potent and selective JAK1 inhibitor
Storage Condition

-20°C
Shipping Condition

Gel Pack
Shelf Life

36 months
SMILES

O=C(C1CC1)NC2=NN3C(C4=CC=C(OCC5=CC=C(C#N)N=C5)C=C4)=CC=CC3=N2
InChi

InChI=1S/C23H18N6O2/c24-12-18-9-4-15(13-25-18)14-31-19-10-7-16(8-11-19)20-2-1-3-21-26-23(28-29(20)21)27-22(30)17-5-6-17/h1-4,7-11,13,17H,5-6,14H2,(H,27,28,30)
InChi Key

QZXABVVSCDZCLR-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes