gp100/ Melanosome/ PMEL17/ SILV

• Catalog number
  GEN438034
• Price
  Please ask
• Size
  100ug

• Also known as
  gp100
• Other names
  melanocyte protein PMEL isoform 2; Melanocyte protein PMEL; melanocyte protein PMEL; melanocyte protein mel 17; silver, mouse, homolog of; melanocyte protein Pmel 17; melanosomal matrix protein17; silver locus protein homolog; melanoma-associated ME20 antigen; melanocytes lineage-specific antigen GP100; premelanosome protein; ME20-M; ME20M; Melanocyte protein Pmel 17; Melanocytes lineage-specific antigen GP100; Melanoma-associated ME20 antigen; P1; P100; Premelanosome protein; Silver locus protein homologCleaved into the following 2 chains:M-alphaAlternative name(s):95 kDa melanocyte-specific secreted glycoprotein; P26; Secreted melanoma-associated ME20 antigen; ME20-S; ME20S
• Category
  Antibodies
• Subcategory
  Mnoclonal antibodies
• Gene name
  SILV
• Gene name synonims
  N/A
• Other gene names
  PMEL; PMEL; P1; SI; SIL; ME20; P100; SILV; ME20M; gp100; ME20-M; PMEL17; D12S53E; D12S53E; PMEL17; SILV; ME20M; ME20-S; ME20S
• Clonality
  Monoclonal
• Immunoglobulin isotype
  IgG1, kappa
• Clone
  HMB45
• Host organism
  Mouse (Mus musculus)
• Species reactivity
  Human (Homo sapiens). Does not react with dog and Rat (Rattus norvegicus). Others-not tested.; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
• Specificity and cross reactivity
  By immunohistochemistry, it specifically recognizes a protein in melanocytes and melanomas. This MAb reacts with junctional and blue nevus cells and variably with fetal and neonatal melanocytes. Intradermal nevi, normal adult melanocytes, and non-melanocytic cells are negative. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin. Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas, large cell lymphomas, and sarcomas using H & E stains alone. It is also difficult to differentiate melanoma from spindle cell carcinomas and various types of mesenchymal neoplasms. Anti-HMB-45 stains fetal and neonatal melanocytes, junctional and blue nevus cells, and malignant melanoma. This MAb also stains Angiomyolipoma (PEComa).; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
• Purification method
  N/A
• Form Appearance
  N/A
• Concentration
  N/A
• Storage and shipping
  Store the antibody at +4C. Temperature variations in the range of 1 to 7 degrees Celsius are tolerable. We recommend NOT to freeze the antibody. Antibody is stable for 24 months.
• Tested applications
  ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), Immunohistology (IH)

• Gene target
  gp100   Melanosome   PMEL17   SILV  
• Gene symbol
  PMEL
• Short name
  gp100/ Melanosome/ PMEL17/ SILV
• Alternative name
  Anti-gp100/ Melanosome/ PMEL17/ SILV

Gene info

• Identity
  HGNC:10880
• Gene
  PMEL
• Long gene name
  premelanosome protein
• Synonyms gene
  • SIL
  • SILV
• Synonyms gene name
  • silver (mouse homolog) like
  • silver homolog (mouse)
• Synonyms
  • D12S53E
  • SI
  • Pmel17
  • gp100
  • HMB-45
  • ME20
• GenBank acession
  • AK092881
• Locus
  12q13.2
• Discovery year
  1997-06-24
• Entrez gene record
  6490
• Pubmed identfication
  • 8739560
• RefSeq identity
  • NM_006928
• VEGA ID
  OTTHUMG00000170573

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