anti-ATM Antibody
-
Catalog number3945
-
PricePlease ask
-
Size0.02 mg, 0.1 mg
-
-
Gene infoATM Antibody: DNA double strand breaks represent a major threat to an organism's genome. Eukaryotic cells have developed mechanisms that sense the presence this damage and initiate suitable responses that can include DNA repair, cell cycle delay, and programmed cell death. The ATM (mutated in Ataxia-Telangiectasia) protein kinase is activated following the formation of DNA double strand breaks, phosphorylating p53 and another kinase CHK2. This initiates a signaling cascade leading to the phosphorylation and inhibition of Cdc25, ultimately preventing cell cycle progression. In some cell types, such as the hemapoietic system, this leads to apoptosis instead of cell cycle arrest. Multiple isoforms of ATM are known to exist.
-
Gene namesATM Antibody: AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, Serine-protein kinase ATM, Ataxia telangiectasia mutated, A-T mutated
-
Antibodie s labelunlabelled serum
-
PurityATM Antibody is affinity chromatography purified via peptide column.
-
Ab raised inRabbit
-
TypePolyclonal
-
ImmunoglobulinIgG
-
AntigenATM antibody was made against a peptide corresponding to 14 amino acids near the carboxy terminus of human ATM.
-
Immuno applicationELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
-
Antibody adviceATM antibody can be used for detection of ATM by Western blot at 1 - 2 ug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 ug/mL. For immunofluorescence start at 10 ug/mL.
-
Suspention pH azideATM Antibody is supplied in PBS containing 0.02% sodium azide.
-
Keep atATM antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
-
Works withHuman
-
Omim nr2304971
-
Ncbi nrAAB65827
-
Vial with antibodyin solution
-
Quantity per ml1 mg/mL
-
NCBI GENE nr472
-
GENE symbolATM
-
Antigene nameataxia telangiectasia mutated
-
SourceHomo sapiens
-
Protein nrQ13315
-
DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
-
PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translationanticorps
-
Gene target
-
Gene symbolATM
-
Short nameanti-ATM Antibody
-
TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
-
Alternative nameAntibody toATM (antibody to-)
-
Alternative techniqueantibodies
-
Alternative to gene targetataxia telangiectasia mutated, AT1 and ATA and ATC and ATD and ATDC and ATE and TEL1 and TELO1, ATM and IDBG-70193 and ENSG00000149311 and 472, transferase activity, nuclei, Atm and IDBG-165511 and ENSMUSG00000034218 and 11920, ATM and IDBG-629882 and ENSBTAG00000003111 and 526824
-
Gene info
-
Identity
-
Gene
-
Long gene nameATM serine/threonine kinase
-
Synonyms gene
-
Synonyms gene name
- ataxia telangiectasia mutated (includes complementation groups A, C and D)
- ataxia telangiectasia mutated
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1995-07-07
-
Entrez gene record
-
RefSeq identity
-
Classification
- Armadillo like helical domain containing
-
VEGA ID
-
Locus Specific Databases
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
