Ki-67 (Proliferation Marker) Antibody, ALEXA FLUOR 488
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Catalog numberbs-2130R-A488
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Price:
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Size100ul
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Long nameKi-67 (Proliferation Marker) Antibody, ALEXA FLUOR 488 Conjugated
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Also known asAnti-Ki-67 proliferation Marker PAb ALEXA FLUOR 488
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CategoryConjugated Primary Antibodies
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Conjugated withALEXA FLUOR® 488
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Host OrganismRabbit (Oryctolagus cuniculus)
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Target AntigenKi-67 proliferation Marker
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SpecificityThis is a highly specific antibody against Ki-67 proliferation Marker.
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ModificationUnmodified
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Modification SiteNone
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ClonalityPolyclonal
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ClonePolyclonal antibody
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Concentration1ug per 1ul
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Immunogen range1250-1300/3256
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Subcellular locationNucleus
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SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Ki67
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Gene ID Number4288
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Swiss ProtP46013
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Tested applicationsIF(IHC-P), IF(ICC)
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Recommended dilutionsIF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
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CrossreactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the antigenProliferation Marker Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine labelling index. The correlation between low Ki67 index and histologically low grade tumours is strong. Ki67 is routinely used as a neuronal marker of cell cycling and proliferation.
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PurificationPurified by Protein A.
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Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
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Excitation emission499nm/519nm
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SynonymsKIA; MIB-; MIB-1; PPP1R15; Antigen KI-67; MKI67
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PropertiesFor facs or microscopy Alexa 1 conjugate. Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-Ki-67 proliferation Marker has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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ConjugationAlexa Fluor
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French translationanticorps
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Gene target
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Gene symbolMKI67P1, MKI67
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Short nameAnti-Ki-67 proliferation Marker
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TechniqueAntibody, antibodies against human proteins, antibodies for, Component cell markers and DNA bp. markers are genetic markers er genes or DNA sequences with a known location on a chromosome that can be used to identify individuals or species. Protein markers in kDA.
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IsotypeImmunoglobulin G (IgG)
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LabelALEXA FLUOR 488
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Alternative nameKi-67 (Proliferation Marker) Antibody, ALEXA FLUOR 488
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namemarker of proliferation Ki-67 pseudogene 1
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Synonyms gene name
- antigen identified by monoclonal antibody Ki-67 pseudogene 1
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Locus
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Discovery year2013-10-10
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Entrez gene record
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemarker of proliferation Ki-67
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Synonyms gene name
- antigen identified by monoclonal antibody Ki-67
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1990-05-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Protein phosphatase 1 regulatory subunits
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data