TCS PIM-1 1

• Catalog number
  2848-10
• Price
  Please ask
• Size
  10 mg

• Alternative_name
  3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
• Description
  TCS PIM-1 1 is a potent, ATP-competitive Pim-1 kinase inhibitor (IC₅₀ = 50 nM). Displays high selectivity over Pim-2 and MEK1/2 (IC₅₀ >20 µM).
• CAS Number
  491871-58-0
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₈H₁₁BrN₂O₂
• Molecular Weight
  367.2
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>35 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent, ATP-competitive Pim-1 kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD00276275
• PubChem CID
  1235170
• PubChem CID Link
• SMILES
  C1=CC=C(C=C1)C2=C(C(=O)NC(=C2)C3=C(C=CC(=C3)Br)O)C#N
• InChi
  InChI=1S/C18H11BrN2O2/c19-12-6-7-17(22)14(8-12)16-9-13(11-4-2-1-3-5-11)15(10-20)18(23)21-16/h1-9,22H,(H,21,23)
• InChi Key
  SVSYJTYGPLVUOZ-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  TCS   PIM-1  
• Gene symbol
  PIM1, TCOF1, LONP1, IGHVII-1-1, MIR1-1, TRUND-NNN8-1, TRUND-NNN7-1, IGKV1OR2-1, MIR1289-1, MIR101-1
• Short name
  TCS PIM-1 1
• Alternative name
  TCS PIM-1 1

Gene info

• Identity
  HGNC:8986
• Gene
  PIM1
• Long gene name
  Pim-1 proto-oncogene, serine/threonine kinase
• Synonyms gene
  • PIM
• Synonyms gene name
  • pim-1 oncogene
• Locus
  6p21.2
• Discovery year
  1986-01-01
• Entrez gene record
  5292
• VEGA ID
  OTTHUMG00000016426

Gene info

• Identity
  HGNC:11654
• Gene
  TCOF1
• Long gene name
  treacle ribosome biogenesis factor 1
• Synonyms gene name
  • Treacher Collins-Franceschetti syndrome 1
• Synonyms
  • treacle
  • TCS
• Locus
  5q32-q33.1
• Discovery year
  1991-05-21
• Entrez gene record
  6949
• Pubmed identfication
  • 1765376
• RefSeq identity
  • NM_001008656
• Classification
  • Ribosomal biogenesis factors
• VEGA ID
  OTTHUMG00000130081
• Locus Specific Databases
  • LOVD TCOF1 mutation database

Gene info

• Identity
  HGNC:9479
• Gene
  LONP1
• Long gene name
  lon peptidase 1, mitochondrial
• Synonyms gene
  • PRSS15
• Synonyms gene name
  • protease, serine, 15
• Synonyms
  • LonHS
  • hLON
  • PIM1
• GenBank acession
  • U02389
• Locus
  19p13.2
• Discovery year
  1999-09-17
• Entrez gene record
  9361
• Pubmed identfication
  • 8248235
  • 8119403
• RefSeq identity
  • NM_004793
• Classification
  • Serine proteases
  • AAA ATPases
• VEGA ID
  OTTHUMG00000180504

Gene info

• Identity
  HGNC:5670
• Gene
  IGHVII-1-1
• Long gene name
  immunoglobulin heavy variable (II)-1-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable (II)-1-1
  • immunoglobulin heavy variable (II)-1-1 pseudogene
• Synonyms
  • IGHV(II)-1-1
• GenBank acession
  • AB019441
• Locus
  14q32.33
• Discovery year
  2000-04-17
• Entrez gene record
  28377
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152325

Gene info

• Identity
  HGNC:31499
• Gene
  MIR1-1
• Long gene name
  microRNA 1-1
• Synonyms gene
  • MIRN1-1
• Synonyms
  • hsa-mir-1-1
• Locus
  20q13.33
• Discovery year
  2004-04-23
• Entrez gene record
  406904
• RefSeq identity
  • NR_029780
• Classification
  • MicroRNA MIR1/206 family

Gene info

• Identity
  HGNC:50820
• Gene
  TRUND-NNN8-1
• Long gene name
  tRNA-undetermined (NNN) 8-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 8-1
• GenBank acession
  • HG984097
• Locus
  1
• Discovery year
  2014-06-20
• Entrez gene record
  103482528
• Pubmed identfication
  • 18984615

Gene info

• Identity
  HGNC:50819
• Gene
  TRUND-NNN7-1
• Long gene name
  tRNA-undetermined (NNN) 7-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 7-1
• GenBank acession
  • HG984096
• Locus
  1
• Discovery year
  2014-06-20
• Entrez gene record
  103482531
• Pubmed identfication
  • 18984615

Gene info

• Identity
  HGNC:5760
• Gene
  IGKV1OR2-1
• Long gene name
  immunoglobulin kappa variable 1/OR2-1 (pseudogene)
• Synonyms gene
  • IGKVPZ1
  • IGKV1OR-1
• Synonyms gene name
  • immunoglobulin kappa variable 1/OR-1
  • immunoglobulin kappa variable 1/OR-1 pseudogene
  • immunoglobulin kappa variable 1/OR-1 (pseudogene)
• Synonyms
  • IGKV1/OR-1
  • IGKV1/OR2-1
• GenBank acession
  • Z12367
• Locus
  2p11.1
• Discovery year
  2000-04-18
• Entrez gene record
  3531
• Pubmed identfication
  • 2853098
• Classification
  • Immunoglobulin kappa (IGK) orphons
• VEGA ID
  OTTHUMG00000155081

Gene info

• Identity
  HGNC:35281
• Gene
  MIR1289-1
• Long gene name
  microRNA 1289-1
• Synonyms gene
  • MIRN1289-1
• Synonyms
  • hsa-mir-1289-1
• Locus
  20q11.22
• Discovery year
  2008-11-03
• Entrez gene record
  100302125
• RefSeq identity
  • NR_031620
• Classification
  • MicroRNA MIR1289 family

Gene info

• Identity
  HGNC:31488
• Gene
  MIR101-1
• Long gene name
  microRNA 101-1
• Synonyms gene
  • MIRN101-1
• Synonyms
  • hsa-mir-101-1
• Locus
  1p31.3
• Discovery year
  2004-04-23
• Entrez gene record
  406893
• RefSeq identity
  • NR_029516
• Classification
  • MicroRNA MIR101 family

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