Wnt-2, human recombinant

• Catalog number
  7599-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  INT1L1, IRP, Int-1-like protein 1, Int-1-related protein
• Alternative_names
  INT1L1, IRP, Int-1-like protein 1, Int-1-related protein
• Description
  Plays a key role in regulating cellular growth and differentiation
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥90%
• Assay
  SDS-PAGE
• Molecular Weight
  39.9 kDa
• Storage Temp
  -20°C
• Shipping
  Gel Pack
• Shelf Life
  12 months
• Appearance
  Lyophilized
• Physical form description
  Lyophilized without additives
• Reconstitution Instructions
  Reconstitute in sterile ddH2O to a concentration ≥ 100 µg/ml.
• Background Information
  This protein belongs to the Wnt family of proteins. The WNT gene family consists of structurally related genes that encode secreted signaling proteins involved in the Wnt signaling pathway. Wnt gene family members, including Wnt-1 through Wnt-10, play a key role in regulating cellular growth and differentiation. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Wnt-2 is expressed in brain in the thalamus, in fetal and adult lung and in the placenta.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Wnt-2  
• Gene symbol
  APC2, FRAT2, NKD2
• Short name
  Wnt-2, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Wnt-2, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:24036
• Gene
  APC2
• Long gene name
  APC regulator of WNT signaling pathway 2
• Synonyms gene name
  • adenomatosis polyposis coli 2
  • APC2, WNT signaling pathway regulator
• Synonyms
  • APCL
• Synonyms name
  • adenomatous polyposis coli like
• Locus
  19p13.3
• Discovery year
  2004-03-18
• Entrez gene record
  10297
• Pubmed identfication
  • 9823329
  • 10021369
• RefSeq identity
  • NM_005883
• Classification
  • Armadillo repeat containing
• VEGA ID
  OTTHUMG00000180059

Gene info

• Identity
  HGNC:16048
• Gene
  FRAT2
• Long gene name
  FRAT regulator of WNT signaling pathway 2
• Synonyms gene name
  • frequently rearranged in advanced T-cell lymphomas 2
  • FRAT2, WNT signaling pathway regulator
• Synonyms name
  • GSK-3 binding protein FRAT2
• GenBank acession
  • AF062739
• Locus
  10q24.1
• Discovery year
  2001-07-06
• Entrez gene record
  23401
• Pubmed identfication
  • 9635432
  • 11237732
• RefSeq identity
  • NM_012083
• VEGA ID
  OTTHUMG00000018850

Gene info

• Identity
  HGNC:17046
• Gene
  NKD2
• Long gene name
  NKD inhibitor of WNT signaling pathway 2
• Synonyms gene name
  • naked cuticle homolog 2 (Drosophila)
  • naked cuticle homolog 2
  • NKD2, WNT signaling pathway inhibitor
• Synonyms
  • Naked2
• Synonyms name
  • naked cuticle-2
  • Dvl-binding protein NKD2
• GenBank acession
  • AF358137
• Locus
  5p15.33
• Discovery year
  2001-10-19
• Entrez gene record
  85409
• Pubmed identfication
  • 11356022
  • 11604995
• RefSeq identity
  • NM_033120
• Classification
  • EF-hand domain containing
• VEGA ID
  OTTHUMG00000090348

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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