Recombinant Human HSPD1 / HSP60 Protein (His & GST tag)
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Catalog numberPKSH031150-50µg
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PricePlease ask
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Size50µg
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SynonymCPN60;GROEL;HLD4;HSP-60;HSP60;HSP65;HuCHA60;SPG13
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ActivityNA
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SequenceLeu 2-Phe 573
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Fusion tagN-His & GST
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AccessionNP_955472.1
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Expressed HostE. coli
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ShippingIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity＞90 % as determined by SDS-PAGE
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EndotoxinPlease contact us for more information.
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Stability and StorageSamples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass88.7 kDa
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AP Mol Mass52-65 kDa
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FormulationLyophilized from sterile PBS, pH 7.4
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BackgroundHSPD1, also known as HSP60, is a member of the chaperonin family. HSPD1 may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. It may also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. HSPD1 gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.Defects in HSPD1 are a cause of spastic paraplegia autosomal dominant type 13 (SPG13). Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Defects in HSPD1 are the cause of leukodystrophy hypomyelinating type 4 (HLD4); also called mitochondrial HSP60 chaperonopathy or MitCHAP-60 disease. HLD4 is a severe autosomal recessive hypomyelinating leukodystrophy. HSPD1 is cinically characterized by infantile-onset rotary nystagmus, progressive spastic paraplegia, neurologic regression, motor impairment, profound mental retardation. Death usually occurrs within the first two decades of life.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
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Conjugationhistidine
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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SourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolHSPD1, MGST3, HSPD1P1, HSPD1P14, HSPD1P20, HSPD1P8, HSPD1P4, HSPD1P16, HSPD1P21, HSPD1P17
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Short nameRecombinant HSPD1 / HSP60 Protein (His & GST tag)
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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LabelHis
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SpeciesHuman, Humans
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Alternative nameRec. H. sapiens heat shock 60kDa protein 1 (chaperonin) / HSP60 Protein (histidine & GST detection labelled)
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Alternative techniquerec
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Alternative to gene targetheat shock 60kDa protein 1 (chaperonin), CPN60 and GROEL and HLD4 and HSP-60 and HSP60 and HSP65 and HuCHA60 and SPG13, HSPD1 and IDBG-77925 and ENSG00000144381 and 3329, chaperone binding, Extracellular, Hspd1 and IDBG-155162 and ENSMUSG00000025980 and 102641967,15510, BT.89909 and IDBG-642936 and ENSBTAG00000012586 and 511913
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Gene info
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Identity
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Gene
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Long gene nameheat shock protein family D (Hsp60) member 1
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Synonyms gene
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Synonyms gene name
- heat shock 60kD protein 1 (chaperonin)
- spastic paraplegia 13 (autosomal dominant)
- heat shock 60kDa protein 1 (chaperonin)
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Synonyms
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GenBank acession
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Locus
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Discovery year1991-07-19
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Chaperonins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicrosomal glutathione S-transferase 3
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1997-10-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Microsomal glutathione S-transferases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameheat shock protein family D (Hsp60) member 1 pseudogene 1
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Synonyms gene name
- heat shock 60kDa protein 1 (chaperonin) pseudogene 1
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Synonyms
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Locus
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Discovery year2008-09-22
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Entrez gene record
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameheat shock protein family D (Hsp60) member 1 pseudogene 14
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Synonyms gene name
- heat shock 60kDa protein 1 (chaperonin) pseudogene 14
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Synonyms
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Locus
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Discovery year2008-09-22
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Entrez gene record
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameheat shock protein family D (Hsp60) member 1 pseudogene 20
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Synonyms gene name
- heat shock 60kDa protein 1 (chaperonin) pseudogene 20
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Synonyms
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Locus
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Discovery year2010-06-25
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Entrez gene record
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RefSeq identity
Gene info
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Identity
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Gene
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Long gene nameheat shock protein family D (Hsp60) member 1 pseudogene 8
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Synonyms gene name
- heat shock 60kDa protein 1 (chaperonin) pseudogene 8
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Synonyms
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Locus
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Discovery year2008-09-22
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Entrez gene record
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameheat shock protein family D (Hsp60) member 1 pseudogene 4
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Synonyms gene name
- heat shock 60kDa protein 1 (chaperonin) pseudogene 4
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Synonyms
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Locus
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Discovery year2008-09-22
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Entrez gene record
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameheat shock protein family D (Hsp60) member 1 pseudogene 16
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Synonyms gene name
- heat shock 60kDa protein 1 (chaperonin) pseudogene 16
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Synonyms
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Locus
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Discovery year2008-09-22
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Entrez gene record
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameheat shock protein family D (Hsp60) member 1 pseudogene 21
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Synonyms gene name
- heat shock 60kDa protein 1 (chaperonin) pseudogene 21
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Synonyms
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Locus
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Discovery year2010-06-25
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Entrez gene record
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameheat shock protein family D (Hsp60) member 1 pseudogene 17
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Synonyms gene name
- heat shock 60kDa protein 1 (chaperonin) pseudogene 17
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Synonyms
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Locus
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Discovery year2008-09-22
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Entrez gene record
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RefSeq identity
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
