Human CellExp™ Frizzled-2 / FZD2 Protein, Human recombinant

• Catalog number
  P1026-50
• Price
  Please ask
• Size
  50 µg

• Synonyms
  FZD2, Frizzled-2, Fz-2, hFz2, FzE2
• Alternative_names
  FZD2, Frizzled-2, Fz-2, hFz2, FzE2
• Recombinant
  Yes
• Source
  HEK 293 cells
• Purity by SDS PAGE
  > 95%
• Assay
  SDS-PAGE
• Molecular Weight
  41.7 kDa
• Storage Temp
  -20°C
• Shipping
  Gel Pack
• Shelf Life
  12 months
• Appearance
  Lyophilized
• Physical form description
  Lyophilized from 0.22 um filtered solution in 50 mM tris, 100 mM glycine, pH 7.5.
• Reconstitution Instructions
  Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex.
• Background Information
  Frizzled-2 (FZD2) is also known as FzE2, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD2 contains one FZ (frizzled) domain. FZD2 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. The Lys-Thr-X-X-X-Trp motif of FZD2 interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CellExp™   Frizzled-2   FZD2   Protein  
• Gene symbol
  FZD2
• Short name
  CellExp™ Frizzled-2 / FZD2 Protein, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Humans
• Alternative name
  H. sapiens CellExp™ Frizzled-2 / FZD2 Protein, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:4040
• Gene
  FZD2
• Long gene name
  frizzled class receptor 2
• Synonyms gene name
  • frizzled (Drosophila) homolog 2
  • frizzled homolog 2 (Drosophila)
  • frizzled 2, seven transmembrane spanning receptor
  • frizzled family receptor 2
• GenBank acession
  • L37882
• Locus
  17q21.31
• Discovery year
  1995-07-18
• Entrez gene record
  2535
• Pubmed identfication
  • 7558010
  • 9813155
• RefSeq identity
  • NM_001466
• Classification
  • G protein-coupled receptors, Class F frizzled
• VEGA ID
  OTTHUMG00000181819

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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