KIRREL1 Antibody, ALEXA FLUOR 647

• Catalog number
  bs-6435R-A647
• Price
  Please ask
• Size
  100ul

• Long name
  KIRREL1 Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
• Also known as
  Anti-KIRREL1 PAb ALEXA FLUOR 647
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 647
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  KIRREL1
• Specificity
  This is a highly specific antibody against KIRREL1.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Subcellular location
  Extracellular
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human KIRREL1/NEPH1
• Gene ID Number
  55243
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Neph1(Kirrel) belongs to a family of three closely related transmembrane proteins of the Ig superfamily with a structure similar to that of nephrin. Neph1 consists of a signal peptide, five Ig-like C2-type domains with the middle domain overlapping with a PKD-like domain, an RGD sequence, a transmembrane domain and a cytoplasmic tail. Neph1 is abundantly expressed in the kidney, specifically expressed in podocytes of kidney glomeruli, and plays a significant role in the normal development and function of the glomerular permeability. Neph1 interacts with nephrin in vitro and in vivo, and able to stimulate transcriptional activation in a model system, such as the activation the transcription factor AP-1 via the stimulation of a MAPK module. Neph1 is crucial for the integrity of the slit diaphragm, as Neph1 gene knockout mice results in effacement of glomerular podocytes, heavy proteinuria, and early postnatal death..Tissue specificity:Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  650nm/665nm
• Synonyms
  Kin of IRRE like Drosophila; Kin of IRRE like; Kin of IRRE like protein 1; Kin of IRRE-like protein 1; Kin of irregular chiasm like protein 1; Kin of irregular chiasm-like protein 1; KIRR1_HUMAN; Kirrel; MGC129542; MGC129543; NEPH 1; NEPH1; Nephrin like protein 1; Nephrin related; Nephrin-like protein 1; KIRR1_HUMAN.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-KIRREL1 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 647
• French translation
  anticorps

• Gene target
  KIRREL1  
• Gene symbol
  KIRREL1, KIRREL1-IT1
• Short name
  Anti-KIRREL1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 647
• Alternative name
  KIRREL1 Polyclonal Antibody, ALEXA FLUOR 647
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:15734
• Gene
  KIRREL1
• Long gene name
  kirre like nephrin family adhesion molecule 1
• Synonyms gene
  • KIRREL
• Synonyms gene name
  • kin of IRRE like (Drosophila)
• Synonyms
  • NEPH1
• Synonyms name
  • nephrin-like protein 1
• GenBank acession
  • AK001707
• Locus
  1q23.1
• Discovery year
  2002-01-22
• Entrez gene record
  55243
• Pubmed identfication
  • 12424224
• RefSeq identity
  • NM_018240
• Classification
  • C2-set domain containing
  • I-set domain containing
• VEGA ID
  OTTHUMG00000022438

Gene info

• Identity
  HGNC:41412
• Gene
  KIRREL1-IT1
• Long gene name
  KIRREL1 intronic transcript 1
• Synonyms gene
  • KIRREL-IT1
• Synonyms gene name
  • KIRREL intronic transcript 1 (non-protein coding)
  • KIRREL intronic transcript 1
• Locus
  1q23.1
• Discovery year
  2011-05-23
• Entrez gene record
  100505785
• RefSeq identity
  • NR_145471
• Classification
  • Intronic transcripts
• VEGA ID
  OTTHUMG00000035615

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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