KIRREL1 Antibody, ALEXA FLUOR 555
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Catalog number
bs-6435R-A555
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Price
Please ask
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Size
100ul
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Long name
KIRREL1 Polyclonal Antibody, ALEXA FLUOR 555 Conjugated
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Also known as
Anti-KIRREL1 PAb ALEXA FLUOR 555
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Category
Conjugated Primary Antibodies
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Conjugated with
ALEXA FLUOR® 555
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Host Organism
Rabbit (Oryctolagus cuniculus)
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Target Antigen
KIRREL1
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Specificity
This is a highly specific antibody against KIRREL1.
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Modification
Unmodified
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Modification Site
None
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Clonality
Polyclonal
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Clone
Polyclonal antibody
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Concentration
1ug per 1ul
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Subcellular location
Extracellular
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Source
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human KIRREL1/NEPH1
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Gene ID Number
55243
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Tested applications
IF(IHC-P)
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Recommended dilutions
IF(IHC-P)(1:50-200)
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Crossreactivity
Human, Mouse, Rat
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Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the antigen
Neph1(Kirrel) belongs to a family of three closely related transmembrane proteins of the Ig superfamily with a structure similar to that of nephrin. Neph1 consists of a signal peptide, five Ig-like C2-type domains with the middle domain overlapping with a PKD-like domain, an RGD sequence, a transmembrane domain and a cytoplasmic tail. Neph1 is abundantly expressed in the kidney, specifically expressed in podocytes of kidney glomeruli, and plays a significant role in the normal development and function of the glomerular permeability. Neph1 interacts with nephrin in vitro and in vivo, and able to stimulate transcriptional activation in a model system, such as the activation the transcription factor AP-1 via the stimulation of a MAPK module. Neph1 is crucial for the integrity of the slit diaphragm, as Neph1 gene knockout mice results in effacement of glomerular podocytes, heavy proteinuria, and early postnatal death..Tissue specificity:Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
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Purification
Purified by Protein A.
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Storage conditions
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
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Excitation emission
553nm/568nm
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Synonyms
Kin of IRRE like Drosophila; Kin of IRRE like; Kin of IRRE like protein 1; Kin of IRRE-like protein 1; Kin of irregular chiasm like protein 1; Kin of irregular chiasm-like protein 1; KIRR1_HUMAN; Kirrel; MGC129542; MGC129543; NEPH 1; NEPH1; Nephrin like protein 1; Nephrin related; Nephrin-like protein 1; KIRR1_HUMAN.
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Properties
For facs or microscopy Alexa 1 conjugate. Very high photo stable ALEXA conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Conjugation
Alexa Fluor, ALEXA FLUOR 555
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French translation
anticorps
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Gene target
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Gene symbol
KIRREL1, KIRREL1-IT1
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Short name
Anti-KIRREL1
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Technique
Antibody, antibodies against human proteins, antibodies for
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Isotype
Immunoglobulin G (IgG)
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Label
ALEXA FLUOR 555
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Alternative name
KIRREL1 Polyclonal Antibody, ALEXA FLUOR 555
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Alternative technique
antibodies
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Gene info
Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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