E-7046

• Catalog number
  B1966-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  4-[(1S)-1-[[[3-(difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]-1H-pyrazol-4-yl]carbonyl]amino]ethyl]-benzoic acid
• Description
  E-7046 is a specific antagonist of the type 4 prostaglandin E2 (PGE2) receptor EP4 (IC₅₀ = 13.5 nM). It possesses significant antitumor growth activity in multiple preclinical tumor models through modulating myeloid cells, including tumor-associated macrophages and myeloid-derived suppressor cells.
• CAS Number
  1369489-71-3
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₂H₁₈F₅N₃O₄
• Molecular Weight
  483.41
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A specific type 4 prostaglandin E2 (PGE2) receptor EP4 atagonist
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  56944705
• PubChem CID Link
• SMILES
  CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C(N(N=C2C(F)F)C)OC3=CC=CC(=C3)C(F)(F)F
• InChi
  InChI=1S/C22H18F5N3O4/c1-11(12-6-8-13(9-7-12)21(32)33)28-19(31)16-17(18(23)24)29-30(2)20(16)34-15-5-3-4-14(10-15)22(25,26)27/h3-11,18H,1-2H3,(H,28,31)(H,32,33)/t11-/m0/s1
• InChi Key
  MKLKAQMPKHNQPR-NSHDSACASA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  E-7046  
• Gene symbol
  HLA-E, SMC2, SNAR-E, IPCEF1, SNRPE, KLRC3, TLE4, IGHV1-69, GUCY2EP
• Short name
  E-7046
• Alternative name
  E-7046

Gene info

• Identity
  HGNC:4962
• Gene
  HLA-E
• Long gene name
  major histocompatibility complex, class I, E
• GenBank acession
  • M20022
• Locus
  6p22.1
• Discovery year
  1988-05-11
• Entrez gene record
  3133
• Pubmed identfication
  • 3131426
• RefSeq identity
  • NM_005516
• Classification
  • C1-set domain containing
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031155
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:14011
• Gene
  SMC2
• Long gene name
  structural maintenance of chromosomes 2
• Synonyms gene
  • SMC2L1
• Synonyms gene name
  • SMC2 (structural maintenance of chromosomes 2, yeast)-like 1
  • SMC2 structural maintenance of chromosomes 2-like 1 (yeast)
• Synonyms
  • hCAP-E
  • CAP-E
• GenBank acession
  • AF092563
• Locus
  9q31.1
• Discovery year
  2001-02-22
• Entrez gene record
  10592
• Pubmed identfication
  • 9789013
• Classification
  • Condensin I subunits
  • Condensin II subunits
  • Structural maintenance of chromosomes proteins
• VEGA ID
  OTTHUMG00000020401

Gene info

• Identity
  HGNC:34325
• Gene
  SNAR-E
• Long gene name
  small NF90 (ILF3) associated RNA E
• Synonyms gene name
  • small ILF3/NF90-associated RNA E
• GenBank acession
  • EU071072
• Locus
  19q13.32
• Discovery year
  2008-07-03
• Entrez gene record
  100170220
• Pubmed identfication
  • 17855395
• RefSeq identity
  • NR_024258
• Classification
  • Small NF90 (ILF3) associated RNAs

Gene info

• Identity
  HGNC:21204
• Gene
  IPCEF1
• Long gene name
  interaction protein for cytohesin exchange factors 1
• Synonyms
  • PIP3-E
  • KIAA0403
• Synonyms name
  • phosphoinositide binding protein PIP3-E
• GenBank acession
  • AB007863
• Locus
  6q25.2
• Discovery year
  2009-02-27
• Entrez gene record
  26034
• Pubmed identfication
  • 11804589
  • 19756519
• RefSeq identity
  • NM_001130699
• Classification
  • Pleckstrin homology domain containing
• VEGA ID
  OTTHUMG00000015872

Gene info

• Identity
  HGNC:11161
• Gene
  SNRPE
• Long gene name
  small nuclear ribonucleoprotein polypeptide E
• Synonyms
  • Sm-E
• GenBank acession
  • M37716
• Locus
  1q32.1
• Discovery year
  1988-11-28
• Entrez gene record
  6635
• Pubmed identfication
  • 1835977
  • 2143747
• RefSeq identity
  • NM_003094
• Classification
  • Sm spliceosomal proteins
• VEGA ID
  OTTHUMG00000035985

Gene info

• Identity
  HGNC:6376
• Gene
  KLRC3
• Long gene name
  killer cell lectin like receptor C3
• Synonyms gene name
  • killer cell lectin-like receptor subfamily C, member 3
• Synonyms
  • NKG2-E
• GenBank acession
  • L14542
• Locus
  12p13.2
• Discovery year
  1998-01-16
• Entrez gene record
  3823
• Pubmed identfication
  • 9598306
• RefSeq identity
  • NM_002261
• Classification
  • C-type lectin domain containing
  • Killer cell lectin like receptors
• VEGA ID
  OTTHUMG00000167149

Gene info

• Identity
  HGNC:11840
• Gene
  TLE4
• Long gene name
  TLE family member 4, transcriptional corepressor
• Synonyms gene name
  • transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
  • transducin like enhancer of split 4
• Synonyms
  • E(spl)
  • ESG
  • GRG4
• GenBank acession
  • M99439
• Locus
  9q21.31
• Discovery year
  1993-12-20
• Entrez gene record
  7091
• Pubmed identfication
  • 8365415
• RefSeq identity
  • NM_001282748
• Classification
  • WD repeat domain containing
  • TLE family
  • Wnt enhanceosome complex
• VEGA ID
  OTTHUMG00000020072

Gene info

• Identity
  HGNC:5558
• Gene
  IGHV1-69
• Long gene name
  immunoglobulin heavy variable 1-69
• Synonyms gene
  • IGHV1-E
• GenBank acession
  • L22582
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28461
• Pubmed identfication
  • 8469934
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000151862

Gene info

• Identity
  HGNC:4690
• Gene
  GUCY2EP
• Long gene name
  guanylate cyclase 2E, pseudogene
• Synonyms gene
  • GUCY2E
• Synonyms gene name
  • guanylate cyclase 2E
• Synonyms
  • GC-E
• Locus
  11q13.5
• Discovery year
  1997-12-05
• Entrez gene record
  390226
• Pubmed identfication
  • 8838319
• RefSeq identity
  • NR_024042
• Classification
  • Guanylate cyclase receptors
• VEGA ID
  OTTHUMG00000165247

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