anti-MRE11 Antibody
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Catalog number5547
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PricePlease ask
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Size0.02 mg, 0.1 mg
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Gene infoMRE11 Antibody: MRE11 is involved in the repair of DNA double strand breaks as part of a complex that includes the Rad50 and NBS1 protein and is thought to act in the same pathway as the A-T mutated (ATM) protein. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for non-homologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Mutations in this protein result in a novel ataxia telangiectasia-like disorder (ATLD). Unlike the ATM protein, MRE11 is necessary proper mammalian development.
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Gene namesMRE11 Antibody: ATLD, HNGS1, MRE11, MRE11B, Double-strand break repair protein MRE11A, Meiotic recombination 11 homolog 1, MRE11 homolog 1
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Antibodie s labelunlabelled serum
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PurityMRE11 Antibody is affinity chromatography purified via peptide column.
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Ab raised inRabbit
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TypePolyclonal
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ImmunoglobulinIgG
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AntigenMRE11 antibody was made against a 14 amino acid synthetic peptide from near the amino terminus human MRE11.
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Immuno applicationELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
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Antibody adviceMRE11 antibody can be used for detection of MRE11 by Western blot at 1 - 2 ug/mL. Antibody can also be used for immunohistochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL.
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Suspention pH azideMRE11 Antibody is supplied in PBS containing 0.02% sodium azide.
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Keep atMRE11 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Works withHuman, Mouse, Rat
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Omim nr119587336
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Ncbi nrEAW66932
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Vial with antibodyin solution
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Quantity per ml1 mg/mL
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NCBI GENE nr4361
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GENE symbolMRE11A
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Antigene nameMRE11 meiotic recombination 11 homolog A (S. cerevisiae)
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SourceHomo sapiens
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Protein nrP49959
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolMRE11
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Short nameanti-MRE11 Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative nameAntibody toMRE11 (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameMRE11 homolog, double strand break repair nuclease
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Synonyms gene
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Synonyms gene name
- MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
- MRE11 homolog A, double strand break repair nuclease
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-05-05
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MRN complex
- MicroRNA protein coding host genes
- BRCA1 C complex
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data