Anti-Catenin, beta Antibody (CTNNB1/1507)

• Catalog number
  A1467-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  CTNNB1
• Target Alternative Name
  Cadherin associated protein, beta 1 88kDa, Catenin beta-1, CATNB, CHBCAT, CTNNB1
• Antibody Type
  Monoclonal
• Clone
  CTNNB1/1507
• Species Reactivities
  Human, mouse, rat
• Immunogen Sequence
  Recombinant human full-length beta-Catenin (p120) protein fragment
• Accession
  P35222
• Gene Id
  1499
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  In 10 mM PBS with 0.05% BSA & 0.05% azide
• Purification
  Protein A/G purification
• Application
  FC, IF, IHC, WB
• Positive Control
  IHC: human Tonsil, human Pancreas, Mouse Colon, Rat Colon
• Application And Usages
  FC: 0.5-1 ug/1X106 cells, IF: 1-2 ug/ml, WB: 0.5-1ug/ml, IHC: 1-2 ug/ml
• Description
  Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans
• Handling
  The antibody solution should be gently mixed before use
• Western Blot Verified
  Not Verified
• Immunocytochemistry Verified
  Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Catenin   beta   CTNNB1/1507  
• Gene symbol
  CTNNB1
• Short name
  Anti-Catenin, beta Antibody (CTNNB1/1507)
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  Mouse / IgG1, kappa
• Alternative name
  Antibody toCatenin, b (antibody to-) (catenin (cadherin-associated protein), b 1, 88kDa/1507)
• Alternative technique
  antibodies
• Alternative to gene target
  catenin (cadherin-associated protein), beta 1, 88kDa, armadillo and CTNNB and MRD19, CTNNB1 and IDBG-27347 and ENSG00000168036 and 1499, repressing transcription factor binding, nuclei, Ctnnb1 and IDBG-205243 and ENSMUSG00000006932 and 12387, CTNNB1 and IDBG-644470 and ENSBTAG00000016420 and 539003

Gene info

• Identity
  HGNC:2514
• Gene
  CTNNB1
• Long gene name
  catenin beta 1
• Synonyms gene
  • CTNNB
• Synonyms gene name
  • catenin (cadherin-associated protein), beta 1 (88kD)
  • catenin (cadherin-associated protein), beta 1, 88kDa
  • catenin (cadherin-associated protein), beta 1
• Synonyms
  • beta-catenin
  • armadillo
• GenBank acession
  • X87838
• Locus
  3p22.1
• Discovery year
  1993-07-13
• Entrez gene record
  1499
• Pubmed identfication
  • 7829088
• RefSeq identity
  • NM_001098210
• Classification
  • Beta catenins
  • Wnt enhanceosome complex
  • Armadillo repeat containing
• VEGA ID
  OTTHUMG00000131393
• Locus Specific Databases
  • LRG_1108

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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