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Synonyms
BAFFR, TNFRSF13C, BAFF-R, BROMIX, CD268, CVID4, prolixin
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Alternative_names
BAFFR, TNFRSF13C, BAFF-R, BROMIX, CD268, CVID4, prolixin
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Description
Promotes the survival of mature B-cells and the B-cell response
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Recombinant
Yes
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Source
HEK293 cells
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Purity by SDS PAGE
> 95%
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Assay
SDS-PAGE
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Endotoxin Level
< 1.0 EU per/ug
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Activity Specifications test method
Measured by its binding ability in a functional ELISA.
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Biological activity
Immobilized Human BAFF, His Tag at 5 ug/mL (100 uL/well) can bind Human BAFFR, Fc Tag with a linear range of 2-31 ng/mL
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Binding Capacity
Immobilized Human BAFF, His Tag at 5 ug/mL (100 uL/well) can bind Human BAFFR, Fc Tag with a linear range of 2-31 ng/mL
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Molecular Weight
33.2 kDa
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Storage Temp
-20°C
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Shipping
Gel Pack
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Shelf Life
12 months
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Appearance
Lyophilized
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Physical form description
Lyophilized from 0.22 um filtered solution in PBS pH 7.4. Generally 5-8% Mannitol or Trehalose is added as a protectant before lyophilization.
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Reconstitution Instructions
Reconstitute in sterile deionized water to a concentration up to 0.2 mg/ml.
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Background Information
BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.
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Handling
Centrifuge the vial prior to opening.
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Usage
For Research Use Only! Not to be used in humans
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
TNFRSF13C
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Short name
CellExp™ BAFFR / TNFRSF13C, Fc Tag Recombinant
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Technique
Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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Label
Fc Tag
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Species
Humans
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Alternative name
H. sapiens CellExp™ BAFFR / tumor necrosis factor receptor superfamily, member 13C, fragment c detection labelled H. sapiens Rec.
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Alternative technique
rec
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Alternative to gene target
tumor necrosis factor receptor superfamily, member 13C, TNFRSF13C and IDBG-9491 and ENSG00000159958 and 115650, Cell surfaces, Tnfrsf13c and IDBG-166389 and ENSMUSG00000068105 and 72049, TNFRSF13C and IDBG-642017 and ENSBTAG00000026489 and 618516
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