c-erbB2 (Herstatin, V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) CD340, C-erbB-2, HER2, HER-2, HER-2/neu, MLN 19, NEU proto-oncogene, NGL, p185erbB2, Receptor tyrosine-protein kinase erbB-2

• Catalog number
  MBS607091
• Price
  Please ask
• Size
  0.1 mg

• Products_type
  Antibody
• Products_short_name
  [c-erbB2]
• Products_name_syn
  [Anti -c-erbB2 (Herstatin, V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) CD340, C-erbB-2, HER2, HER-2, HER-2/neu, MLN 19, NEU proto-oncogene, NGL, p185erbB2, Receptor tyrosine-protein kinase erbB-2]
• Other_names
  [Chain P, Single Chain Fv Of C219 Heavy Chain V101l Mutant In Complex With Synthetic Epitope Peptide]
• Clonality
  Monoclonal
• Clone
  [9H75]
• Reactivity
  Human
• Specificity
  Recognizes recombinant human Herstatin and recombinant human ErbB2. Does not crossreact with recombinant human EGFR or recombinant human ERbB3.
• Purity
  Affinity Purified Purified by Protein G affinity chromatography.
• Form
  Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.
• Storage_stability
  Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
• Tested_application
  Immunohistochemistry (IHC)
• Description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

• Gene target
  c-erbB2   Herstatin   V-erb-b2   erythroblastic   leukemia   viral   oncogene   homolog   glioblastoma   derived   oncogene   homolog   avian   CD340   C-erbB-2   HER2   HER-2   HER-2/neu   MLN   NEU   proto-oncogene   NGL   p185erbB2   Receptor   tyrosine-protein   kinase   erbB-2  
• Gene symbol
  ERBB2, MLN, MIR7-2, MIR329-2, MIR512-2, MIR521-2, MIR1289-2, MIR509-2, KRTAP13-2, RNU6-2
• Short name
  c-erbB2 (Herstatin, V-erb-b2 erythroblastic leukemia oncogene homolog 2, /glioblastoma derived oncogene homolog (avian) CD340, C-erbB-2, HER2, HER-2, HER-2/neu, MLN 19, NEU proto-oncogene, NGL, p185erbB2, Receptor tyrosine-protein kinase erbB-2
• Host
  Mouse
• Isotype
  IgG2b
• Alternative name
  c-v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (Herstatin, V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) CD340, C-erbB-2, HER2, HER-2, HER-2/neu, MLN 19, NEU proto-oncogene, NGL, p185erbB2, Receptor tyrosine-protein phosphorylation catalyst erbB-2
• Alternative to gene target
  v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian), CD340 and HER-2 and HER-2/neu and HER2 and MLN 19 and NEU and NGL and TKR1, ERBB2 and IDBG-46068 and ENSG00000141736 and 2064, transferase activity, nuclei, Erbb2 and IDBG-210591 and ENSMUSG00000062312 and 13866, ERBB2 and IDBG-639410 and ENSBTAG00000021798 and 505709
• Virus
  leukemia

Gene info

• Identity
  HGNC:3430
• Gene
  ERBB2
• Long gene name
  erb-b2 receptor tyrosine kinase 2
• Synonyms gene
  • NGL
• Synonyms gene name
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
• Synonyms
  • NEU
  • HER-2
  • CD340
  • HER2
• Synonyms name
  • neuro/glioblastoma derived oncogene homolog
  • human epidermal growth factor receptor 2
• GenBank acession
  • X03363
• Locus
  17q12
• Discovery year
  2001-06-22
• Entrez gene record
  2064
• RefSeq identity
  • NM_004448
• Classification
  • Erb-b2 receptor tyrosine kinases
  • CD molecules
  • Minor histocompatibility antigens
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000179300
• Locus Specific Databases
  • LRG_724

Gene info

• Identity
  HGNC:7141
• Gene
  MLN
• Long gene name
  motilin
• Synonyms name
  • prepromotilin
• Locus
  6p21.31
• Discovery year
  1988-08-05
• Entrez gene record
  4295
• Classification
  • Neuropeptides
• VEGA ID
  OTTHUMG00000014536

Gene info

• Identity
  HGNC:31639
• Gene
  MIR7-2
• Long gene name
  microRNA 7-2
• Synonyms gene
  • MIRN7-2
• Synonyms
  • hsa-mir-7-2
• Locus
  15q26.1
• Discovery year
  2004-04-23
• Entrez gene record
  407044
• RefSeq identity
  • NR_029606
• Classification
  • MicroRNA MIR7 family

Gene info

• Identity
  HGNC:32051
• Gene
  MIR329-2
• Long gene name
  microRNA 329-2
• Synonyms gene
  • MIRN329-2
• Synonyms
  • hsa-mir-329-2
• Locus
  14q32.31
• Discovery year
  2005-07-11
• Entrez gene record
  574409
• RefSeq identity
  • NR_029968
• Classification
  • MicroRNA MIR329 family

Gene info

• Identity
  HGNC:32091
• Gene
  MIR512-2
• Long gene name
  microRNA 512-2
• Synonyms gene
  • MIRN512-2
• Synonyms
  • hsa-mir-512-2
• Locus
  19q13.42
• Discovery year
  2005-07-15
• Entrez gene record
  574459
• RefSeq identity
  • NR_030181
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:32113
• Gene
  MIR521-2
• Long gene name
  microRNA 521-2
• Synonyms gene
  • MIRN521-2
• Synonyms
  • hsa-mir-521-2
• Locus
  19q13.42
• Discovery year
  2005-07-15
• Entrez gene record
  574481
• RefSeq identity
  • NR_030203
• Classification
  • MicroRNA MIR515 family

Gene info

• Identity
  HGNC:35282
• Gene
  MIR1289-2
• Long gene name
  microRNA 1289-2
• Synonyms gene
  • MIRN1289-2
• Synonyms
  • hsa-mir-1289-2
• Locus
  5q31.1
• Discovery year
  2008-11-03
• Entrez gene record
  100302134
• RefSeq identity
  • NR_031621
• Classification
  • MicroRNA MIR1289 family

Gene info

• Identity
  HGNC:33641
• Gene
  MIR509-2
• Long gene name
  microRNA 509-2
• Synonyms gene
  • MIRN509-2
• Synonyms
  • hsa-mir-509-2
• Locus
  Xq27.3
• Discovery year
  2007-10-24
• Entrez gene record
  100126301
• RefSeq identity
  • NR_030586
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:18923
• Gene
  KRTAP13-2
• Long gene name
  keratin associated protein 13-2
• Synonyms
  • KAP13-2
• GenBank acession
  • AP001708
• Locus
  21q22.11
• Discovery year
  2003-02-21
• Entrez gene record
  337959
• Pubmed identfication
  • 12359730
• Classification
  • Keratin associated proteins
• VEGA ID
  OTTHUMG00000057793

Gene info

• Identity
  HGNC:34270
• Gene
  RNU6-2
• Long gene name
  RNA, U6 small nuclear 2
• Synonyms
  • U6-2
• Locus
  19p13.3
• Discovery year
  2008-06-10
• Entrez gene record
  103625684
• Pubmed identfication
  • 12711679
• RefSeq identity
  • NR_125730
• Classification
  • Small nuclear RNAs

MeSH Data

• Name
  Leukemia, Experimental
• Concept
  Scope note: Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.
• Tree numbers
  • C04.557.337.372
  • C04.619.531
  • E05.598.500.496.500
• Qualifiers
  diagnosis, parasitology, immunology, microbiology, diagnostic imaging, physiopathology, rehabilitation, enzymology, etiology, mortality, epidemiology, blood, cerebrospinal fluid, chemically induced, congenital, diet therapy, drug therapy, therapy, psychology, urine, virology, history, classification, economics, embryology, genetics, nursing, radiotherapy, ethnology, prevention & control, pathology, metabolism, complications, surgery

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