Gigaxonin Antibody, ALEXA FLUOR 350

• Catalog number
  bs-11025R-A350
• Price
  Please ask
• Size
  100ul

• Long name
  Gigaxonin Polyclonal Antibody, ALEXA FLUOR 350 Conjugated
• Also known as
  Anti-Gigaxonin PAb ALEXA FLUOR 350
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 350
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  Gigaxonin
• Specificity
  This is a highly specific antibody against Gigaxonin.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Gigaxonin
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Gigaxonin, also refered to as giant axonal neuropathy, GAN1, or KLHL16, controls protein degradation and is essential for neuronal function and survival. Gigaxonin is a member of the cytoskeletal BTB/kelch repeat family and influences cytoskeletal organization and dynamics, playing a large role in neurofilament architecture. The amino terminal BTB domain of gigaxonin binds to the ubiquitin-activating enzyme E1, while the carboxy-terminal kelch repeat domain interacts directly with the light chain of microtubule-associated protein 1B (MAP1B), and tags it for degredation. Overexpression of MAP1B may lead to neuronal cell death, whereas a reduction of MAP1B significantly improves the survival rate of neurons. Mutations in the Gigaxonin gene result in human giant axonal neuropathy (GAN), an autosomal recessive neurodegenerative disorder characterized by axonal degeneration caused by cytoskeletal abnormalities, including accumulated intermediate filaments.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  343nm/442nm
• Synonyms
  FLJ38059; GAN; GAN1; Kelch-like protein 16; giant axonal neuropathy; KLHL16; GAN_HUMAN.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 350
• French translation
  anticorps

• Gene target
  Gigaxonin  
• Gene symbol
  GAN
• Short name
  Anti-Gigaxonin
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 350
• Alternative name
  Gigaxonin Polyclonal Antibody, ALEXA FLUOR 350
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:4137
• Gene
  GAN
• Long gene name
  gigaxonin
• Synonyms gene name
  • giant axonal neuropathy (gigaxonin)
• Synonyms
  • GAN1
  • KLHL16
  • GIG
• Synonyms name
  • kelch-like family member 16
• GenBank acession
  • AF291673
• Locus
  16q23.2
• Discovery year
  1998-09-14
• Entrez gene record
  8139
• Pubmed identfication
  • 9450783
  • 11062483
• Classification
  • BTB domain containing
  • Kelch like
• VEGA ID
  OTTHUMG00000137627
• Locus Specific Databases
  • Inherited Peripheral Neuropathies Mutation Database
  • LRG_242

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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