ABC294640

Alternative_name

1S,3R,5R,7S)-3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide
Description

ABC294640 is a specific spingosine kinase-2 (SK-2) inhibitor having antineoplastic activity. This orally available aryl admantane molecule upon administration binds and inhibits SK-2, preventing phosphorylation of the pro-apoptotic amino alcohol spingosine to spingosine-1-phosphate (S1P), the lipid mediator that is important for immunomodulation, this phosphorylation prevention of amino alcohol can induce apoptosis and may inhibit cancer cell proliferation.
CAS Number

915385-81-8
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₃H₂₅ClN₂O
Molecular Weight

380.91
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO(>4 mg/ml)
Handling

Protect from air and light
Tag Line

A specific spingosine kinase-2 (SK-2) inhibitor having antineoplastic activity.
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

71587865
PubChem CID Link
SMILES

C1C2CC3(CC1CC(C2)(C3)C(=O)NCC4=CC=NC=C4)C5=CC=C(C=C5)Cl
InChi

InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27)/t17-,18?,22?,23?/m0/s1
InChi Key

CAOTVXGYTWCKQE-RZTFFZPQSA-N
Data Sheet Link
MSDS Available

Yes