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CD437 for cell activation

CD437 for cell activation is available 2 times from Biovision labs

2636-25 | CD437 for cell activation size: 25 mg | 671.55 USD

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2636-5 | CD437 for cell activation size: 5 mg | 224.99 USD

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Other name 6-​(4-​hydroxy-​3-​tricyclo[3.3.1.13,​7]dec-​1-​ylphenyl)-​2-​naphthalenecarboxylic acid; AHPN
Supplied with N/A
Description CD437 is the adamantyl arotinoid of the retinoid-related molecule family that acts as a selective agonist of retinoic acid receptor (RAR)γ (Kds = 6.5 μM, 2.5 μM, and 77 nM for RARα, β, and γ, respectively). CD437 is cytotoxic to the acute myeloid leukemia cell line NB4 (EC₅₀ = 0.17 μM), inducing DNA damage by producing DNA double strand breaks. CD437 also induces cell cycle arrest and apoptosis in various other cancer cells including melanoma, breast, non-small lung, and prostate cancer cells through RAR-dependent and -independent signaling pathways. Treatment of mouse embryonic fibroblasts (MEFs) with CD437 early in the reprogramming process significantly increases reprogramming efficiency up to 20-fold.
Category Biochemicals
Molecular formula C₂₇H₂₆O₃
Is it cell-permeable? Yes
Molecular weight 398.49
Storage condition -20 ̊C
Shipping condition Gel pack
Purification >95%
Peptide sequence N/A
Is this a salt? No
CAS number 125316-60-1
Storage instructions Protect from air and light
Maximum time for storage 36 months
Physical appearance White solid
Reconstitute instructions DMSO (>10 mg/ml)
Additional description For cells, cell lines and tissues in culture till half confluency.
Gene targetCD437 for activation
Short name CD437 for activation
Technique activation
Alternative name CD437 to measure cellular activation
Tissue cell
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