6-(4-hydroxy-3-tricyclo[188.8.131.52,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid; AHPN
CD437 is the adamantyl arotinoid of the retinoid-related molecule family that acts as a selective agonist of retinoic acid receptor (RAR)γ (Kds = 6.5 μM, 2.5 μM, and 77 nM for RARα, β, and γ, respectively). CD437 is cytotoxic to the acute myeloid leukemia cell line NB4 (EC₅₀ = 0.17 μM), inducing DNA damage by producing DNA double strand breaks. CD437 also induces cell cycle arrest and apoptosis in various other cancer cells including melanoma, breast, non-small lung, and prostate cancer cells through RAR-dependent and -independent signaling pathways. Treatment of mouse embryonic fibroblasts (MEFs) with CD437 early in the reprogramming process significantly increases reprogramming efficiency up to 20-fold.
Is it cell-permeable?
Is this a salt?
Protect from air and light
Maximum time for storage
DMSO (>10 mg/ml)
For cells, cell lines and tissues in culture till half confluency.